PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
dipeptidyl peptidase like 10ENSG00000175497DPP10chr2:114442299-115845752:+Tbio36.4732
solute carrier family 4 member 11ENSG00000088836SLC4A11chr20:3227417-3239190:-Tbio70.704
phospholipase C beta 3ENSG00000149782PLCB3chr11:64251523-64269150:+Tbio68.4967
C-X-C motif chemokine receptor 1ENSG00000163464CXCR1chr2:218162845-218166995:-Tchem273.778
signaling threshold regulating transmembrane adaptor 1ENSG00000137078SIT1chr9:35649295-35650950:-Tdark45.9151
BCL2 like 14ENSG00000121380BCL2L14chr12:12049844-12211084:+Tbio13.9132
solute carrier family 10 member 3ENSG00000126903SLC10A3chrX:154487306-154490690:-Tdark191.579
interleukin 17DENSG00000172458IL17Dchr13:20702127-20723098:+Tbio8.71189
adhesion G protein-coupled receptor L4ENSG00000162618ADGRL4chr1:78889764-79006718:-Tbio14.963
jade family PHD finger 3ENSG00000102221JADE3chrX:46912276-47061242:+Tbio0.7
leucine rich repeat containing 4CENSG00000148948LRRC4Cchr11:40114203-41459773:-Tbio204.833
DDB1 and CUL4 associated factor 1ENSG00000145041VPRBPchr3:51395867-51500002:-Tbio54.5107
interleukin 31 receptor AENSG00000164509IL31RAchr5:55851379-55922853:+Tbio296.108
mucin 15, cell surface associatedENSG00000169550MUC15chr11:26559033-26572233:-Tbio25.7188
chymase 1ENSG00000092009CMA1chr14:24505353-24508265:-Tchem479.497
tyrosyl-tRNA synthetase 1ENSG00000134684YARSchr1:32775237-32818153:-Tchem49.2294
TNF receptor associated protein 1ENSG00000126602TRAP1chr16:3651639-3717597:-Tchem84.8853
ADAM metallopeptidase with thrombospondin type 1 motif 9ENSG00000163638ADAMTS9chr3:64515654-64688000:-Tbio29.9417
kynureninaseENSG00000115919KYNUchr2:142877498-143055832:+Tchem21.3032
membrane bound transcription factor peptidase, site 2ENSG00000012174MBTPS2chrX:21839636-21885424:+Tbio79.3687

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