PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
sulfotransferase family 2B member 1ENSG00000088002SULT2B1chr19:48552075-48599425:+Tbio32.0195
solute carrier family 6 member 9ENSG00000196517SLC6A9chr1:43991500-44031467:-Tchem153.873
retinol binding protein 2ENSG00000114113RBP2chr3:139452884-139480747:-Tbio62.8835
leucine rich repeat containing G protein-coupled receptor 6ENSG00000133067LGR6chr1:202193901-202319781:+Tbio60.1193
interferon induced transmembrane protein 1ENSG00000185885IFITM1chr11:313506-315272:+Tbio108.056
MORC family CW-type zinc finger 2ENSG00000133422MORC2chr22:30925130-30968298:-Tbio8.6131
tryptase alpha/beta 1ENSG00000172236TPSAB1chr16:1240696-1242554:+Tclin73.0667
leukocyte immunoglobulin like receptor B2ENSG00000131042LILRB2chr19:54238904-54281184:-Tbio25.5
integrin subunit alpha 7ENSG00000135424ITGA7chr12:55684568-55716043:-Tbio41.3863
collagen type IX alpha 3 chainENSG00000092758COL9A3chr20:62816244-62841159:+Tbio41.9786
protein kinase C substrate 80K-HENSG00000130175PRKCSHchr19:11435288-11450968:+Tbio43.9786
tudor domain containing 5ENSG00000162782TDRD5chr1:179591613-179691272:+Tdark1.5
hexosaminidase subunit alphaENSG00000213614HEXAchr15:72340919-72376476:-Tchem633.7
tripartite motif containing 21ENSG00000132109TRIM21chr11:4384897-4393696:-Tbio967.565
arachidonate 15-lipoxygenase type BENSG00000179593ALOX15Bchr17:8039017-8049134:+Tchem58.9764
cystatin AENSG00000121552CSTAchr3:122325244-122341972:+Tbio101.585
solute carrier family 5 member 8ENSG00000256870SLC5A8chr12:101155493-101210407:-Tbio58.603
transmembrane serine protease 3ENSG00000160183TMPRSS3chr21:42371890-42396846:-Tbio50.9416
cyclin dependent kinase 12ENSG00000167258CDK12chr17:39461511-39564907:+Tbio15.885
nuclear receptor subfamily 1 group D member 1ENSG00000126368NR1D1chr17:40092787-40100725:-Tchem79.6779

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