PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| TP53 regulated inhibitor of apoptosis 1 | ENSG00000170855 | TRIAP1 | chr12:120443961-120446412:- | Tbio | 17.2333 |
| matrix metallopeptidase 8 | ENSG00000118113 | MMP8 | chr11:102711795-102727050:- | Tchem | 514.179 |
| leucine rich repeat and Ig domain containing 1 | ENSG00000169783 | LINGO1 | chr15:77613027-77820900:- | Tbio | 93.9119 |
| lysine demethylase 1A | ENSG00000004487 | KDM1A | chr1:23019448-23083689:+ | Tchem | 325.667 |
| tryptase gamma 1 | ENSG00000116176 | TPSG1 | chr16:1221651-1225257:- | Tchem | 254.474 |
| L3MBTL histone methyl-lysine binding protein 1 | ENSG00000185513 | L3MBTL1 | chr20:43507680-43550950:+ | Tchem | 27.4298 |
| BR serine/threonine kinase 2 | ENSG00000174672 | BRSK2 | chr11:1389899-1462689:+ | Tchem | 61.1231 |
| collagen type IV alpha 4 chain | ENSG00000081052 | COL4A4 | chr2:227002711-227164113:- | Tbio | 76.7808 |
| microtubule affinity regulating kinase 3 | ENSG00000075413 | MARK3 | chr14:103385392-103503831:+ | Tchem | 230.033 |
| arachidonate 15-lipoxygenase | ENSG00000161905 | ALOX15 | chr17:4630902-4642294:- | Tchem | 537.718 |
| solute carrier family 47 member 1 | ENSG00000142494 | SLC47A1 | chr17:19495385-19579034:+ | Tchem | 70.1096 |
| chondroitin sulfate proteoglycan 5 | ENSG00000114646 | CSPG5 | chr3:47562239-47580792:- | Tbio | 9.94167 |
| uridine phosphorylase 1 | ENSG00000183696 | UPP1 | chr7:48088628-48108733:+ | Tchem | 51.8083 |
| G protein-coupled receptor 17 | ENSG00000144230 | GPR17 | chr2:127645864-127652639:+ | Tchem | 82.0512 |
| solute carrier family 35 member E3 | ENSG00000175782 | SLC35E3 | chr12:68746106-68793964:+ | Tdark | 0.2625 |
| dickkopf WNT signaling pathway inhibitor 2 | ENSG00000155011 | DKK2 | chr4:106921802-107283806:- | Tbio | 30.1394 |
| R-spondin 4 | ENSG00000101282 | RSPO4 | chr20:958452-1002264:- | Tbio | 17.2936 |
| coiled-coil domain containing 3 | ENSG00000151468 | CCDC3 | chr10:12896625-13099652:- | Tbio | 2.2 |
| PHD finger protein 1 | ENSG00000112511 | PHF1 | chr6:33410399-33416453:+ | Tbio | 255.71 |
| dipeptidyl peptidase like 6 | ENSG00000130226 | DPP6 | chr7:153887097-154894285:+ | Tbio | 77.7264 |
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