PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
interleukin 20ENSG00000162891IL20chr1:206865354-206869223:+Tbio70.2469
glutathione S-transferase alpha 2ENSG00000244067GSTA2chr6:52750089-52763569:-Tbio77.433
peptidylprolyl isomerase HENSG00000171960PPIHchr1:42658425-42676758:+Tbio11.9004
solute carrier family 39 member 8ENSG00000138821SLC39A8chr4:102251041-102431258:-Tbio26.2856
ATP binding cassette subfamily G member 8ENSG00000143921ABCG8chr2:43838964-43878466:+Tbio127.224
carbohydrate sulfotransferase 6ENSG00000183196CHST6chr16:75472052-75495384:-Tbio70.8457
Wnt family member 5BENSG00000111186WNT5Bchr12:1529891-1647243:+Tbio26.7428
carboxypeptidase X, M14 family member 1ENSG00000088882CPXM1chr20:2794069-2800637:-Tdark2.29167
histamine receptor H3ENSG00000101180HRH3chr20:62214970-62220267:-Tclin334.434
methyltransferase like 22ENSG00000067365METTL22chr16:8621683-8649654:+Tdark0.875
amelotinENSG00000187689AMTNchr4:70518540-70532742:+Tbio5.36068
solute carrier family 7 member 7ENSG00000155465SLC7A7chr14:22773222-22829820:-Tbio61.5221
G protein-coupled receptor 68ENSG00000119714GPR68chr14:91232532-91253925:-Tbio35.2095
adenosine monophosphate deaminase 3ENSG00000133805AMPD3chr11:10308313-10507579:+Tchem145.667
transglutaminase 5ENSG00000104055TGM5chr15:43232595-43266857:-Tbio34.6854
peroxiredoxin 4ENSG00000123131PRDX4chrX:23664262-23686399:+Tbio93.4276
cystatin CENSG00000101439CST3chr20:23626706-23638473:-Tbio2883.86
mixed lineage kinase domain like pseudokinaseENSG00000168404MLKLchr16:74671855-74700960:-Tbio46.3173
cytochrome P450 family 46 subfamily A member 1ENSG00000036530CYP46A1chr14:99684304-99727301:+Tbio100.071
potassium inwardly rectifying channel subfamily J member 14ENSG00000182324KCNJ14chr19:48455509-48466980:+Tdark9.1546

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