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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
solute carrier family 7 member 2	ENSG00000003989	SLC7A2	chr8:17497088-17570573:+	Tbio	96.2786
cellular communication network factor 6	ENSG00000112761	WISP3	chr6:112054072-112070969:+	Tbio	99.9672
EPH receptor B1	ENSG00000154928	EPHB1	chr3:134597801-135260467:+	Tchem	36.6896
fibrillin 3	ENSG00000142449	FBN3	chr19:8065402-8149846:-	Tbio	18.9838
prostaglandin F receptor	ENSG00000122420	PTGFR	chr1:78303884-78539749:+	Tclin	82.7962
activating transcription factor 1	ENSG00000123268	ATF1	chr12:50763710-50821122:+	Tchem	117.684
prolyl 3-hydroxylase 1	ENSG00000117385	P3H1	chr1:42746335-42767084:-	Tbio	24.6817
protein phosphatase methylesterase 1	ENSG00000214517	PPME1	chr11:74171099-74254703:+	Tchem	17.525
solute carrier family 26 member 2	ENSG00000155850	SLC26A2	chr5:149960737-149993455:+	Tbio	134.791
carboxypeptidase B2	ENSG00000080618	CPB2	chr13:46053186-46105076:-	Tchem	514.731
interleukin 13 receptor subunit alpha 2	ENSG00000123496	IL13RA2	chrX:115003975-115019977:-	Tbio	134.247
G protein-coupled receptor 146	ENSG00000164849	GPR146	chr7:1044576-1059261:+	Tdark	2.63016
acid phosphatase 6, lysophosphatidic	ENSG00000162836	ACP6	chr1:147629652-147670496:-	Tbio	9.0911
interleukin 17B	ENSG00000127743	IL17B	chr5:149371324-149404202:-	Tbio	33.3964
TBC1 domain containing kinase	ENSG00000145348	TBCK	chr4:106041599-106321495:-	Tbio	5.78125
SCY1 like pseudokinase 1	ENSG00000142186	SCYL1	chr11:65525077-65538704:+	Tbio	30.8857
carbonyl reductase 3	ENSG00000159231	CBR3	chr21:36134912-36146566:+	Tbio	46.1078
translocator protein	ENSG00000100300	TSPO	chr22:43151514-43163242:+	Tchem	966.183
adrenoceptor alpha 2B	ENSG00000274286	ADRA2B	chr2:96112875-96116245:-	Tclin	148.313
calcium voltage-gated channel auxiliary subunit gamma 2	ENSG00000166862	CACNG2	chr22:36563921-36703558:-	Tbio	54.4135

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