PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
G protein-coupled receptor 4ENSG00000177464GPR4chr19:45589764-45602208:-Tchem30.8984
solute carrier family 26 member 6ENSG00000225697SLC26A6chr3:48625723-48635493:-Tbio35.2199
protein tyrosine phosphatase receptor type HENSG00000080031PTPRHchr19:55181248-55209506:-Tbio14.4929
arginine vasopressin receptor 1AENSG00000166148AVPR1Achr12:63142759-63150942:-Tclin155.566
phospholipase C beta 4ENSG00000101333PLCB4chr20:9068763-9481242:+Tbio29.6738
neuroligin 1ENSG00000169760NLGN1chr3:173396284-174286644:+Tbio97.1742
alpha-L-fucosidase 1ENSG00000179163FUCA1chr1:23845077-23868294:-Tchem125.902
TATA-box binding protein associated factor 1ENSG00000147133TAF1chrX:71366239-71532374:+Tbio194.559
interferon gamma receptor 2ENSG00000159128IFNGR2chr21:33402896-33479348:+Tbio184.153
interleukin 1 receptor associated kinase 3ENSG00000090376IRAK3chr12:66188879-66254622:+Tchem50.554
dual specificity phosphatase 26ENSG00000133878DUSP26chr8:33591332-33600106:-Tbio66.9845
hydroxysteroid 17-beta dehydrogenase 4ENSG00000133835HSD17B4chr5:119452443-119637199:+Tbio79.7743
lymphocyte antigen 9ENSG00000122224LY9chr1:160796074-160828261:+Tbio24.8797
influenza virus NS1A binding proteinENSG00000116679IVNS1ABPchr1:185296388-185317329:-Tbio1282.62
intercellular adhesion molecule 3ENSG00000076662ICAM3chr19:10333776-10339823:-Tbio144.868
interleukin 15 receptor subunit alphaENSG00000134470IL15RAchr10:5937569-5978187:-Tbio88.6297
decapping enzyme, scavengerENSG00000110063DCPSchr11:126303752-126345749:+Tbio69.225
fibroblast growth factor binding protein 1ENSG00000137440FGFBP1chr4:15935569-15938740:-Tbio35.5832
acid phosphatase 1ENSG00000143727ACP1chr2:264140-278283:+Tchem247.12
collagen type VIII alpha 1 chainENSG00000144810COL8A1chr3:99638475-99799226:+Tbio16.2614

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