PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ladinin 1ENSG00000159166LAD1chr1:201373244-201399915:-Tbio88.605
serine peptidase inhibitor Kazal type 5ENSG00000133710SPINK5chr5:148025683-148137289:+Tbio141.821
diacylglycerol lipase betaENSG00000164535DAGLBchr7:6409126-6484190:-Tchem4.50519
protein kinase cAMP-dependent type II regulatory subunit betaENSG00000005249PRKAR2Bchr7:107044649-107161811:+Tbio67.7171
endoplasmic reticulum aminopeptidase 1ENSG00000164307ERAP1chr5:96760810-96808100:-Tchem161.993
G protein-coupled receptor kinase 3ENSG00000100077ADRBK2chr22:25564849-25729294:+Tchem57.8968
IGF like family member 1ENSG00000188293IGFL1chr19:46229752-46231243:+Tdark2.65833
glucagon receptorENSG00000215644GCGRchr17:81804132-81814013:+Tclin236.277
laminin subunit alpha 5ENSG00000130702LAMA5chr20:62307955-62367312:-Tbio47.4164
collagen type VI alpha 1 chainENSG00000142156COL6A1chr21:45981737-46005050:+Tbio85.7969
solute carrier family 16 member 2ENSG00000147100SLC16A2chrX:74421461-74533917:+Tbio156.233
G protein-coupled receptor 160ENSG00000173890GPR160chr3:170037929-170085403:+Tbio5.77424
solute carrier family 29 member 2ENSG00000174669SLC29A2chr11:66362521-66372214:-Tbio87.1798
potassium inwardly rectifying channel subfamily J member 2ENSG00000123700KCNJ2chr17:70168673-70180048:+Tbio390.012
caspase recruitment domain family member 8ENSG00000105483CARD8chr19:48180770-48255946:-Tbio66.0002
collagen type VIII alpha 2 chainENSG00000171812COL8A2chr1:36095236-36125220:-Tbio97.9266
proliferation-associated 2G4ENSG00000170515PA2G4chr12:56104319-56113907:+Tbio65.0189
EGF like repeats and discoidin domains 3ENSG00000164176EDIL3chr5:83940554-84384793:-Tbio57.9092
solute carrier family 29 member 1 (Augustine blood group)ENSG00000112759SLC29A1chr6:44219505-44234151:+Tclin325.369
transient receptor potential cation channel subfamily V member 3ENSG00000167723TRPV3chr17:3510502-3557995:-Tchem86.1276

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