PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
holocarboxylase synthetaseENSG00000159267HLCSchr21:36750888-36990236:-Tchem312.446
tyrosyl-tRNA synthetase 2ENSG00000139131YARS2chr12:32727490-32755902:-Tbio25.0107
antizyme inhibitor 2ENSG00000142920AZIN2chr1:33081104-33120530:+Tbio97.2119
SLAM family member 6ENSG00000162739SLAMF6chr1:160485030-160523262:-Tbio34.2421
heparanase 2 (inactive)ENSG00000172987HPSE2chr10:98457077-99235862:-Tbio75.3052
activin A receptor type 2AENSG00000121989ACVR2Achr2:147844517-147930826:+Tchem76.0252
claudin 18ENSG00000066405CLDN18chr3:137998735-138033655:+Tbio39.2816
laminin subunit gamma 1ENSG00000135862LAMC1chr1:183023460-183145592:+Tbio49.1506
serpin family B member 7ENSG00000166396SERPINB7chr18:63752935-63805376:+Tbio46.1857
phosphodiesterase 2AENSG00000186642PDE2Achr11:72576141-72674591:-Tclin41.3474
troponin C1, slow skeletal and cardiac typeENSG00000114854TNNC1chr3:52451102-52454070:-Tclin164.185
arachidonate lipoxygenase 3ENSG00000179148ALOXE3chr17:8095900-8119047:-Tbio24.2972
solute carrier family 19 member 2ENSG00000117479SLC19A2chr1:169463909-169486003:-Tbio99.6254
eukaryotic translation initiation factor 2 alpha kinase 2ENSG00000055332EIF2AK2chr2:37099210-37157065:-Tbio700.035
VRK serine/threonine kinase 1ENSG00000100749VRK1chr14:96797304-96931722:+Tbio69.1209
protein tyrosine phosphatase non-receptor type 23ENSG00000076201PTPN23chr3:47381011-47413441:+Tbio22.4213
mitogen-activated protein kinase kinase 3ENSG00000034152MAP2K3chr17:21284672-21315240:+Tchem66.7105
ADAM metallopeptidase with thrombospondin type 1 motif 2ENSG00000087116ADAMTS2chr5:179110851-179345430:-Tbio44.6774
granzyme KENSG00000113088GZMKchr5:55024253-55034570:+Tbio31.8053
galactosidase beta 1ENSG00000170266GLB1chr3:32996608-33097230:-Tchem3591.65

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