PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
YES proto-oncogene 1, Src family tyrosine kinaseENSG00000176105YES1chr18:721588-812546:-Tclin87.081
lectin, mannose binding 1ENSG00000074695LMAN1chr18:59327823-59359962:-Tbio132.927
inositol 1,4,5-trisphosphate receptor type 2ENSG00000123104ITPR2chr12:26336515-26833198:-Tbio43.9595
hydroxysteroid 17-beta dehydrogenase 7ENSG00000132196HSD17B7chr1:162790702-162812817:+Tchem370.082
arylsulfatase AENSG00000100299ARSAchr22:50622754-50628173:-Tbio650.378
Wnt family member 9AENSG00000143816WNT9Achr1:227918656-227947898:-Tbio15.7431
TATA-box binding protein associated factor 3ENSG00000165632TAF3chr10:7818504-8016627:+Tbio13.8274
CD72 moleculeENSG00000137101CD72chr9:35609533-35646810:-Tbio57.3152
peptidase inhibitor 16ENSG00000164530PI16chr6:36948263-36964837:+Tbio5.05119
egl-9 family hypoxia inducible factor 2ENSG00000269858EGLN2chr19:40798996-40808433:+Tchem66.914
aldehyde dehydrogenase 1 family member L1ENSG00000144908ALDH1L1chr3:126103562-126197994:-Tbio71.0874
cholinergic receptor muscarinic 3ENSG00000133019CHRM3chr1:239386565-239915452:+Tclin425.829
phospholipase C beta 2ENSG00000137841PLCB2chr15:40278176-40307935:-Tbio89.8302
galectin 8ENSG00000116977LGALS8chr1:236518000-236552981:+Tchem110.362
ADAM metallopeptidase domain 10ENSG00000137845ADAM10chr15:58588807-58749978:-Tchem332.52
MAPK interacting serine/threonine kinase 1ENSG00000079277MKNK1chr1:46557408-46616843:-Tchem52.2432
prokineticin 1ENSG00000143125PROK1chr1:110451200-110457354:+Tbio184.665
kinase suppressor of ras 1ENSG00000141068KSR1chr17:27456714-27626438:+Tbio100.74
junctional adhesion molecule 2ENSG00000154721JAM2chr21:25639272-25717562:+Tbio37.8087
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gammaENSG00000139144PIK3C2Gchr12:18247614-18648416:+Tchem8.81667

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