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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
glucagon like peptide 1 receptor	ENSG00000112164	GLP1R	chr6:39048798-39087743:+	Tclin	848.836
sodium channel epithelial 1 subunit beta	ENSG00000168447	SCNN1B	chr16:23278231-23381299:+	Tclin	63.5588
solute carrier family 24 member 2	ENSG00000155886	SLC24A2	chr9:19507452-19786928:-	Tbio	29.4468
synaptojanin 1	ENSG00000159082	SYNJ1	chr21:32628759-32728048:-	Tbio	40.9911
adrenoceptor alpha 1B	ENSG00000170214	ADRA1B	chr5:159916783-159972544:+	Tclin	139.255
fatty acid binding protein 2	ENSG00000145384	FABP2	chr4:119317250-119322390:-	Tchem	385.436
carnitine palmitoyltransferase 1C	ENSG00000169169	CPT1C	chr19:49690898-49713731:+	Tbio	18.0547
serine/threonine kinase 4	ENSG00000101109	STK4	chr20:44966474-45079959:+	Tchem	15.1147
lipase C, hepatic type	ENSG00000166035	LIPC	chr15:58410569-58569843:+	Tchem	759.705
opioid binding protein/cell adhesion molecule like	ENSG00000183715	OPCML	chr11:132414977-133532519:-	Tbio	44.2489
kallikrein related peptidase 13	ENSG00000167759	KLK13	chr19:51056206-51065114:-	Tbio	26.3158
sphingolipid transporter 3 (putative)	ENSG00000182557	SPNS3	chr17:4433688-4488208:+	Tdark	0.333333
UDP-glucose glycoprotein glucosyltransferase 1	ENSG00000136731	UGGT1	chr2:128091200-128195677:+	Tbio	28.7107
diacylglycerol O-acyltransferase 1	ENSG00000185000	DGAT1	chr8:144314584-144326910:-	Tclin	154.874
gamma-aminobutyric acid type A receptor subunit delta	ENSG00000187730	GABRD	chr1:2019324-2030751:+	Tclin	19.4651
hyaluronan and proteoglycan link protein 2	ENSG00000132702	HAPLN2	chr1:156619294-156625725:+	Tbio	5.49444
interferon alpha and beta receptor subunit 1	ENSG00000142166	IFNAR1	chr21:33324477-33359862:+	Tclin	192.621
galectin 9	ENSG00000168961	LGALS9	chr17:27629798-27649560:+	Tchem	166.977
complement C1r	ENSG00000159403	C1R	chr12:7080209-7092607:-	Tclin	219.349
bone morphogenetic protein 8b	ENSG00000116985	BMP8B	chr1:39757182-39788861:-	Tbio	48.9006

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