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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
enhancer of zeste 2 polycomb repressive complex 2 subunit	ENSG00000106462	EZH2	chr7:148807383-148884321:-	Tchem	933.017
zeta chain of T cell receptor associated protein kinase 70	ENSG00000115085	ZAP70	chr2:97713560-97739862:+	Tchem	1050.46
coagulation factor II, thrombin	ENSG00000180210	F2	chr11:46719180-46739506:+	Tclin	17181.6
protein arginine methyltransferase 1	ENSG00000126457	PRMT1	chr19:49675786-49689029:+	Tchem	184.747
protein C, inactivator of coagulation factors Va and VIIIa	ENSG00000115718	PROC	chr2:127418427-127429246:+	Tchem	1643.33
3-hydroxy-3-methylglutaryl-CoA reductase	ENSG00000113161	HMGCR	chr5:75336329-75362104:+	Tclin	1829.27
CD1c molecule	ENSG00000158481	CD1C	chr1:158289786-158293630:+	Tbio	735.185
caspase 8	ENSG00000064012	CASP8	chr2:201233443-201287711:+	Tchem	2090.69
angiopoietin like 4	ENSG00000167772	ANGPTL4	chr19:8363289-8374373:+	Tbio	205.243
dopamine beta-hydroxylase	ENSG00000123454	DBH	chr9:133636360-133659344:+	Tchem	1559.3
chromodomain helicase DNA binding protein 7	ENSG00000171316	CHD7	chr8:60678778-60868028:+	Tbio	321.661
ADAM metallopeptidase domain 12	ENSG00000148848	ADAM12	chr10:126012381-126388455:-	Tchem	226.34
flap structure-specific endonuclease 1	ENSG00000168496	FEN1	chr11:61792637-61797244:+	Tchem	334.401
phosphoinositide-3-kinase regulatory subunit 1	ENSG00000145675	PIK3R1	chr5:68215720-68301821:+	Tchem	383.968
lon peptidase 1, mitochondrial	ENSG00000196365	LONP1	chr19:5691834-5720572:-	Tbio	215.492
haptoglobin	ENSG00000257017	HP	chr16:72054592-72061055:+	Tbio	2996.52
TNF receptor superfamily member 10a	ENSG00000104689	TNFRSF10A	chr8:23190452-23225126:-	Tchem	404.932
DNA methyltransferase 1	ENSG00000130816	DNMT1	chr19:10133345-10231286:-	Tclin	979.326
purinergic receptor P2Y12	ENSG00000169313	P2RY12	chr3:151337380-151384812:-	Tclin	1218.96
RAR related orphan receptor C	ENSG00000143365	RORC	chr1:151806071-151831872:-	Tchem	590.612

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