PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ATPase H+ transporting V1 subunit DENSG00000100554ATP6V1Dchr14:67294371-67360265:-Tbio4.91001
leishmanolysin like peptidaseENSG00000185621LMLNchr3:197960200-198043720:+Tdark152.127
TANK binding kinase 1ENSG00000183735TBK1chr12:64451880-64502108:+Tchem340.021
5-hydroxytryptamine receptor 2BENSG00000135914HTR2Bchr2:231108230-231125118:-Tclin175.632
STE20 related adaptor alphaENSG00000266173STRADAchr17:63702832-63741970:-Tbio20.4482
aldehyde dehydrogenase 7 family member A1ENSG00000164904ALDH7A1chr5:126541841-126595418:-Tbio167.817
gamma-aminobutyric acid type B receptor subunit 1ENSG00000204681GABBR1chr6:29555629-29633976:-Tclin344.878
alpha-1-microglobulin/bikunin precursorENSG00000106927AMBPchr9:114060127-114078472:-Tbio447.813
p21 (RAC1) activated kinase 3ENSG00000077264PAK3chrX:110944285-111227361:+Tchem44.8637
carbohydrate sulfotransferase 12ENSG00000136213CHST12chr7:2403560-2448483:+Tbio5.02587
retinoic acid induced 1ENSG00000108557RAI1chr17:17681473-17811453:+Tbio82.9976
ADAM metallopeptidase domain 19ENSG00000135074ADAM19chr5:157395534-157575775:-Tbio34.0103
TGF-beta activated kinase 1 (MAP3K7) binding protein 2ENSG00000055208TAB2chr6:149218641-149411613:+Tbio28.3749
G protein-coupled receptor 87ENSG00000138271GPR87chr3:151294086-151316952:-Tbio11.6145
tachykinin precursor 3ENSG00000166863TAC3chr12:57010000-57028883:-Tchem239.401
platelet derived growth factor CENSG00000145431PDGFCchr4:156760454-156971394:-Tbio73.5872
adhesion G protein-coupled receptor B1ENSG00000181790ADGRB1chr8:142449430-142545009:+Tbio33.0669
nuclear receptor binding protein 1ENSG00000115216NRBP1chr2:27427790-27442259:+Tbio30.1
phosphoribosyl pyrophosphate amidotransferaseENSG00000128059PPATchr4:56393362-56435615:-Tclin46.1302
inositol 1,4,5-trisphosphate receptor type 3ENSG00000096433ITPR3chr6:33620365-33696574:+Tchem597.247

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