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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
arachidonate 12-lipoxygenase, 12S type	ENSG00000108839	ALOX12	chr17:6996065-7010736:+	Tchem	120.782
C3 and PZP like alpha-2-macroglobulin domain containing 8	ENSG00000160111	CPAMD8	chr19:16892947-17026815:-	Tbio	5.78333
RecQ like helicase	ENSG00000004700	RECQL	chr12:21468911-21501669:-	Tbio	82.5731
WAP four-disulfide core domain 1	ENSG00000103175	WFDC1	chr16:84294646-84329851:+	Tbio	54.3099
proline rich acidic protein 1	ENSG00000165828	PRAP1	chr10:133309410-133352683:+	Tdark	193.324
potassium voltage-gated channel subfamily D member 3	ENSG00000171385	KCND3	chr1:111770662-111989155:-	Tclin	208.07
chloride voltage-gated channel Kb	ENSG00000184908	CLCNKB	chr1:16043736-16057308:+	Tchem	97.4869
slit guidance ligand 3	ENSG00000184347	SLIT3	chr5:168661733-169301129:-	Tbio	31.519
calcitonin receptor like receptor	ENSG00000064989	CALCRL	chr2:187343129-187448460:-	Tchem	119.055
adenosine monophosphate deaminase 2	ENSG00000116337	AMPD2	chr1:109616104-109632051:+	Tchem	25.2364
nucleoporin 210	ENSG00000132182	NUP210	chr3:13316235-13420309:-	Tbio	73.2532
suprabasin	ENSG00000189001	SBSN	chr19:35523367-35528351:-	Tbio	8.96212
matrix metallopeptidase 19	ENSG00000123342	MMP19	chr12:55835433-55842966:-	Tbio	69.8652
islet amyloid polypeptide	ENSG00000121351	IAPP	chr12:21354959-21379978:+	Tbio	1407.42
reticulon 4 receptor	ENSG00000040608	RTN4R	chr22:20241415-20283246:-	Tbio	140.535
galactosamine (N-acetyl)-6-sulfatase	ENSG00000141012	GALNS	chr16:88813734-88856970:-	Tbio	363.549
CD84 molecule	ENSG00000066294	CD84	chr1:160541095-160579516:-	Tbio	24.5268
solute carrier family 6 member 17	ENSG00000197106	SLC6A17	chr1:110150486-110202202:+	Tbio	2.66667
ECRG4 augurin precursor	ENSG00000119147	C2orf40	chr2:106063246-106078159:+	Tbio	40.2838
gamma-aminobutyric acid type A receptor subunit alpha3	ENSG00000011677	GABRA3	chrX:152166234-152451358:-	Tclin	36.2699

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