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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
matrix metallopeptidase 17	ENSG00000198598	MMP17	chr12:131828393-131851783:+	Tchem	26.8969
slit guidance ligand 1	ENSG00000187122	SLIT1	chr10:96998038-97185920:-	Tbio	16.4818
FXYD domain containing ion transport regulator 2	ENSG00000137731	FXYD2	chr11:117800844-117828698:-	Tclin	30.6734
mutS homolog 6	ENSG00000116062	MSH6	chr2:47695530-47810101:+	Tbio	545.793
peptidyl arginine deiminase 3	ENSG00000142619	PADI3	chr1:17249098-17284233:+	Tchem	28.2667
metal response element binding transcription factor 2	ENSG00000143033	MTF2	chr1:93079235-93139081:+	Tbio	50.3433
transglutaminase 3	ENSG00000125780	TGM3	chr20:2296001-2341078:+	Tchem	68.1062
solute carrier family 20 member 1	ENSG00000144136	SLC20A1	chr2:112645857-112663827:+	Tbio	41.9604
ribophorin I	ENSG00000163902	RPN1	chr3:128619970-128681075:-	Tbio	53.8754
ATPase H+ transporting V0 subunit c	ENSG00000185883	ATP6V0C	chr16:2513726-2520223:+	Tbio	21.2571
glucagon	ENSG00000115263	GCG	chr2:162142873-162152404:-	Tchem	2331.05
potassium voltage-gated channel subfamily B member 1	ENSG00000158445	KCNB1	chr20:49363877-49482647:-	Tclin	214.578
proteasome 20S subunit beta 9	ENSG00000240065	PSMB9	chr6:32844136-32859585:+	Tchem	284.17
lysosomal associated membrane protein 1	ENSG00000185896	LAMP1	chr13:113297241-113323672:+	Tbio	468.397
surfactant protein A1	ENSG00000122852	SFTPA1	chr10:79610939-79615455:+	Tbio	1163.19
solute carrier family 17 member 9	ENSG00000101194	SLC17A9	chr20:62952647-62969585:+	Tbio	19.3611
cytochrome P450 family 4 subfamily B member 1	ENSG00000142973	CYP4B1	chr1:46757838-46819413:+	Tbio	40.5438
interleukin 1 receptor accessory protein	ENSG00000196083	IL1RAP	chr3:190514051-190659750:+	Tclin	52.1583
malonyl-CoA decarboxylase	ENSG00000103150	MLYCD	chr16:83899126-83927026:+	Tchem	72.061
integrin subunit beta 6	ENSG00000115221	ITGB6	chr2:160099666-160271888:-	Tbio	28.7623

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