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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
ADAM metallopeptidase domain 11	ENSG00000073670	ADAM11	chr17:44759031-44781846:+	Tbio	19.5004
bromodomain containing 1	ENSG00000100425	BRD1	chr22:49773283-49827512:-	Tchem	27.5143
fatty acid binding protein 6	ENSG00000170231	FABP6	chr5:160187367-160238735:+	Tbio	61.7845
phospholipase C like 1 (inactive)	ENSG00000115896	PLCL1	chr2:197804702-198572581:+	Tbio	66.4254
phosphodiesterase 4A	ENSG00000065989	PDE4A	chr19:10416773-10469631:+	Tclin	691.342
Fc fragment of IgG receptor IIIb	ENSG00000162747	FCGR3B	chr1:161623196-161631963:-	Tbio	207.962
semaphorin 7A (John Milton Hagen blood group)	ENSG00000138623	SEMA7A	chr15:74409289-74434467:-	Tbio	47.127
ATPase H+ transporting V1 subunit B1	ENSG00000116039	ATP6V1B1	chr2:70935882-70965406:+	Tchem	51.6881
solute carrier family 40 member 1	ENSG00000138449	SLC40A1	chr2:189560579-189583758:-	Tchem	234.272
glypican 5	ENSG00000179399	GPC5	chr13:91398675-92873682:+	Tbio	47.983
syndecan 4	ENSG00000124145	SDC4	chr20:45325288-45348424:-	Tbio	183.687
tubulin alpha 1a	ENSG00000167552	TUBA1A	chr12:49184796-49189324:-	Tchem	46.8136
ADAM metallopeptidase domain 9	ENSG00000168615	ADAM9	chr8:38996869-39105144:+	Tchem	108.017
sterol O-acyltransferase 1	ENSG00000057252	SOAT1	chr1:179293714-179358680:+	Tchem	227.839
TXK tyrosine kinase	ENSG00000074966	TXK	chr4:48066393-48134256:-	Tchem	294.261
DS cell adhesion molecule	ENSG00000171587	DSCAM	chr21:40010999-40847139:-	Tbio	54.4672
UDP glucuronosyltransferase family 1 member A10	ENSG00000242515	UGT1A10	chr2:233636454-233773305:+	Tbio	67.9191
sepiapterin reductase	ENSG00000116096	SPR	chr2:72887360-72892158:+	Tbio	704.829
neurexin 1	ENSG00000179915	NRXN1	chr2:49918505-51032561:-	Tbio	117.901
cellular communication network factor 5	ENSG00000064205	WISP2	chr20:44714844-44728509:+	Tbio	51.7735

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