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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
tuftelin 1	ENSG00000143367	TUFT1	chr1:151540305-151583583:+	Tbio	25.4087
CD9 molecule	ENSG00000010278	CD9	chr12:6199715-6238271:+	Tbio	422.971
solute carrier family 17 member 7	ENSG00000104888	SLC17A7	chr19:49429401-49442360:-	Tbio	91.5306
mucin 13, cell surface associated	ENSG00000173702	MUC13	chr3:124905442-124953819:-	Tbio	19.4412
ADAMTS like 1	ENSG00000178031	ADAMTSL1	chr9:18473894-18910950:+	Tbio	6.19812
BMP2 inducible kinase	ENSG00000138756	BMP2K	chr4:78776342-78916372:+	Tchem	13.8472
R-spondin 1	ENSG00000169218	RSPO1	chr1:37611350-37634923:-	Tbio	100.314
complement C9	ENSG00000113600	C9	chr5:39284262-39424868:-	Tbio	336.28
leukocyte receptor tyrosine kinase	ENSG00000062524	LTK	chr15:41503638-41513887:-	Tchem	35.2702
FRAS1 related extracellular matrix 1	ENSG00000164946	FREM1	chr9:14734666-14910995:-	Tbio	58.2667
coagulation factor XIII A chain	ENSG00000124491	F13A1	chr6:6144085-6321013:-	Tchem	503.253
sphingolipid transporter 1 (putative)	ENSG00000169682	SPNS1	chr16:28974221-28984548:+	Tbio	95.9489
retinaldehyde binding protein 1	ENSG00000140522	RLBP1	chr15:89209869-89221751:-	Tbio	102.788
Wnt family member 4	ENSG00000162552	WNT4	chr1:22117305-22143969:-	Tbio	124.141
cerebellin 1 precursor	ENSG00000102924	CBLN1	chr16:49277917-49281831:-	Tbio	13.8778
corticotropin releasing hormone receptor 1	ENSG00000120088	CRHR1	chr17:45784280-45835828:+	Tclin	413.486
hematopoietic prostaglandin D synthase	ENSG00000163106	HPGDS	chr4:94298535-94342876:-	Tchem	108.675
solute carrier family 39 member 7	ENSG00000112473	SLC39A7	chr6:33200445-33204439:+	Tbio	18.0727
aminoadipate aminotransferase	ENSG00000109576	AADAT	chr4:170060222-170091699:-	Tchem	47.2183
vasohibin 1	ENSG00000071246	VASH1	chr14:76762189-76783015:+	Tbio	49.671

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