PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
nitric oxide synthase 1ENSG00000089250NOS1chr12:117208142-117452170:-Tchem1313.43
selenoprotein PENSG00000250722SEPP1chr5:42799880-42887392:-Tbio106.116
interleukin 12 receptor subunit beta 1ENSG00000096996IL12RB1chr19:18058995-18098944:-Tbio132.113
BR serine/threonine kinase 1ENSG00000160469BRSK1chr19:55282072-55312533:+Tchem31.2513
5-hydroxytryptamine receptor 2AENSG00000102468HTR2Achr13:46831550-46897076:-Tclin2266.3
interleukin 27ENSG00000197272IL27chr16:28499362-28512051:-Tbio290.935
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1ENSG00000203857HSD3B1chr1:119507198-119515054:+Tchem426.6
protein tyrosine phosphatase non-receptor type 7ENSG00000143851PTPN7chr1:202147013-202161588:-Tchem21.9706
carbonic anhydrase 8ENSG00000178538CA8chr8:60187347-60281412:-Tbio68.4595
signal peptidase complex subunit 3ENSG00000129128SPCS3chr4:176319964-176332245:+Tdark13.8833
inositol-trisphosphate 3-kinase BENSG00000143772ITPKBchr1:226631690-226739323:-Tbio27.3657
C1q and TNF related 6ENSG00000133466C1QTNF6chr22:37180167-37199385:-Tbio5.66454
UL16 binding protein 1ENSG00000111981ULBP1chr6:149964007-149973710:+Tbio36.0685
inositol-trisphosphate 3-kinase AENSG00000137825ITPKAchr15:41493393-41503551:+Tbio28.9512
interleukin 17 receptor BENSG00000056736IL17RBchr3:53846580-53865800:+Tbio55.679
myosin light chain kinase 2ENSG00000101306MYLK2chr20:31819308-31834689:+Tbio13.8444
arylsulfatase LENSG00000157399ARSEchrX:2934632-2968310:-Tbio299.821
membrane metalloendopeptidase like 1ENSG00000142606MMEL1chr1:2590639-2632990:-Tchem60.3042
TRAF2 and NCK interacting kinaseENSG00000154310TNIKchr3:171061339-171460408:-Tchem15.0273
TNF receptor superfamily member 18ENSG00000186891TNFRSF18chr1:1203508-1206691:-Tbio93.9771

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