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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
peripheral myelin protein 2	ENSG00000147588	PMP2	chr8:81440326-81447523:-	Tbio	38.8392
ATPase H+ transporting V1 subunit A	ENSG00000114573	ATP6V1A	chr3:113747019-113812056:+	Tbio	8.38439
flavin containing dimethylaniline monoxygenase 5	ENSG00000131781	FMO5	chr1:147175351-147243050:-	Tbio	24.4663
peptidylprolyl isomerase like 4	ENSG00000131013	PPIL4	chr6:149504733-149546038:-	Tdark	1.75
interferon beta 1	ENSG00000171855	IFNB1	chr9:21077105-21077963:-	Tbio	2458.51
protein kinase D1	ENSG00000184304	PRKD1	chr14:29576479-30191898:-	Tchem	367.698
Scm polycomb group protein like 2	ENSG00000102098	SCML2	chrX:18239314-18354727:-	Tbio	11.0643
proteasome 26S subunit, ATPase 1	ENSG00000100764	PSMC1	chr14:90256495-90275429:+	Tbio	10.2195
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2	ENSG00000107742	SPOCK2	chr10:72059035-72089032:-	Tbio	9.38491
interleukin 13 receptor subunit alpha 1	ENSG00000131724	IL13RA1	chrX:118727572-118794539:+	Tbio	55.5238
3-hydroxy-3-methylglutaryl-CoA synthase 2	ENSG00000134240	HMGCS2	chr1:119747996-119768905:-	Tbio	63.3766
tyrosyl-DNA phosphodiesterase 1	ENSG00000042088	TDP1	chr14:89954939-90044768:+	Tchem	90.1579
huntingtin	ENSG00000197386	HTT	chr4:3074681-3243959:+	Tchem	1681.79
TNF receptor superfamily member 21	ENSG00000146072	TNFRSF21	chr6:47231532-47309905:-	Tbio	98.1502
sphingosine-1-phosphate receptor 2	ENSG00000267534	S1PR2	chr19:10221435-10231272:-	Tchem	82.7977
potassium voltage-gated channel subfamily Q member 4	ENSG00000117013	KCNQ4	chr1:40784012-40840452:+	Tclin	104.864
activin A receptor like type 1	ENSG00000139567	ACVRL1	chr12:51906908-51923361:+	Tchem	256.644
solute carrier family 39 member 10	ENSG00000196950	SLC39A10	chr2:195575977-195737702:+	Tbio	10.7147
potassium voltage-gated channel subfamily Q member 3	ENSG00000184156	KCNQ3	chr8:132120859-132480953:-	Tclin	105.971
calcium/calmodulin dependent protein kinase II alpha	ENSG00000070808	CAMK2A	chr5:150219491-150290291:-	Tchem	46.4903

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