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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
hepatocyte growth factor	ENSG00000019991	HGF	chr7:81699006-81770438:-	Tchem	2448.44
mucin 16, cell surface associated	ENSG00000181143	MUC16	chr19:8848844-8981342:-	Tbio	3783.1
chromobox 2	ENSG00000173894	CBX2	chr17:79778132-79787983:+	Tchem	38.7047
melanocortin 1 receptor	ENSG00000258839	MC1R	chr16:89912119-89920977:+	Tclin	591.825
cyclin dependent kinase 7	ENSG00000134058	CDK7	chr5:69234795-69277430:+	Tchem	507.358
lysine acetyltransferase 2B	ENSG00000114166	KAT2B	chr3:20040023-20154404:+	Tchem	390.087
angiotensinogen	ENSG00000135744	AGT	chr1:230702523-230714297:-	Tbio	10892.8
coagulation factor XII	ENSG00000131187	F12	chr5:177402140-177409576:-	Tchem	895.604
protein kinase C beta	ENSG00000166501	PRKCB	chr16:23836001-24220611:+	Tchem	383.809
NIMA related kinase 2	ENSG00000117650	NEK2	chr1:211658657-211675630:-	Tchem	119.472
transient receptor potential cation channel subfamily M member 8	ENSG00000144481	TRPM8	chr2:233917398-234019522:+	Tclin	287.671
fibronectin 1	ENSG00000115414	FN1	chr2:215360440-215436172:-	Tchem	768.337
interleukin 6	ENSG00000136244	IL6	chr7:22725884-22732002:+	Tclin	22090
cell division cycle 25B	ENSG00000101224	CDC25B	chr20:3786772-3806121:+	Tchem	166.535
COP9 signalosome subunit 5	ENSG00000121022	COPS5	chr8:67043079-67083783:-	Tbio	138.135
glutathione S-transferase pi 1	ENSG00000084207	GSTP1	chr11:67583595-67586660:+	Tchem	1659.44
poly(ADP-ribose) polymerase 1	ENSG00000143799	PARP1	chr1:226360691-226408079:-	Tclin	4119.44
BLM RecQ like helicase	ENSG00000197299	BLM	chr15:90717327-90816165:+	Tchem	158.234
ATP binding cassette subfamily G member 2 (Junior blood group)	ENSG00000118777	ABCG2	chr4:88090264-88231322:-	Tchem	1791.58
thymidine kinase 1	ENSG00000167900	TK1	chr17:78174075-78187233:-	Tchem	247.793

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