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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

Show entries each page Jump to page Total Page: 305 Total entries: 6083
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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
glutathione S-transferase omega 1	ENSG00000148834	GSTO1	chr10:104235356-104267459:+	Tchem	171.373
cystatin S	ENSG00000101441	CST4	chr20:23685640-23689040:-	Tbio	39.004
histone deacetylase 3	ENSG00000171720	HDAC3	chr5:141620876-141636870:-	Tclin	276.043
anterior gradient 3, protein disulphide isomerase family member	ENSG00000173467	AGR3	chr7:16859405-16881987:-	Tbio	52.1262
kelch like family member 9	ENSG00000198642	KLHL9	chr9:21329671-21335380:-	Tbio	2.28333
crumbs cell polarity complex component 2	ENSG00000148204	CRB2	chr9:123356170-123380324:+	Tbio	20.0142
bromodomain and WD repeat domain containing 3	ENSG00000165288	BRWD3	chrX:80670854-80809688:-	Tbio	6.69762
ATPase phospholipid transporting 8A1	ENSG00000124406	ATP8A1	chr4:42408373-42657105:-	Tbio	52.0417
lysyl oxidase like 4	ENSG00000138131	LOXL4	chr10:98247690-98268250:-	Tbio	26.1028
interleukin 12 receptor subunit beta 2	ENSG00000081985	IL12RB2	chr1:67307364-67396900:+	Tbio	46.8016
EGF like domain multiple 7	ENSG00000172889	EGFL7	chr9:136658856-136672678:+	Tbio	59.425
toll like receptor 8	ENSG00000101916	TLR8	chrX:12906620-12923169:+	Tchem	196.304
DNA topoisomerase I mitochondrial	ENSG00000184428	TOP1MT	chr8:143304384-143359979:-	Tclin	9.51115
alcohol dehydrogenase 4 (class II), pi polypeptide	ENSG00000198099	ADH4	chr4:99123657-99157792:-	Tbio	59.0234
poly(ADP-ribose) polymerase family member 15	ENSG00000173200	PARP15	chr3:122577602-122639047:+	Tbio	213.117
frizzled class receptor 3	ENSG00000104290	FZD3	chr8:28494205-28574268:+	Tbio	42.234
histamine N-methyltransferase	ENSG00000150540	HNMT	chr2:137964020-138016364:+	Tchem	375.424
sodium channel epithelial 1 subunit alpha	ENSG00000111319	SCNN1A	chr12:6346843-6377730:-	Tclin	130.566
phosphoinositide-3-kinase regulatory subunit 2	ENSG00000105647	PIK3R2	chr19:18153118-18170540:+	Tbio	303.114
histidine rich glycoprotein	ENSG00000113905	HRG	chr3:186660216-186678240:+	Tbio	175.892

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