PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
apolipoprotein C3ENSG00000110245APOC3chr11:116829706-116833072:+Tbio678.294
interleukin 2ENSG00000109471IL2chr4:122451470-122456725:-Tchem16378.3
purinergic receptor P2Y1ENSG00000169860P2RY1chr3:152834693-152841439:+Tchem353.558
hedgehog acyltransferaseENSG00000054392HHATchr1:210328252-210676296:+Tbio100.608
granzyme MENSG00000197540GZMMchr19:544034-549924:+Tbio180.024
pygopus family PHD finger 1ENSG00000171016PYGO1chr15:55538890-55588947:-Tdark2.32504
histidine rich calcium binding proteinENSG00000130528HRCchr19:49151198-49155424:-Tbio32.2095
tudor domain containing 1ENSG00000095627TDRD1chr10:114179270-114232304:+Tbio4.67798
PR/SET domain 8ENSG00000152784PRDM8chr4:80183879-80204329:+Tbio2.74167
adhesion G protein-coupled receptor L3ENSG00000150471ADGRL3chr4:61201258-62078335:+Tbio84.6467
ATP binding cassette subfamily C member 9ENSG00000069431ABCC9chr12:21797401-21941402:-Tclin84.9391
cytochrome P450 family 2 subfamily C member 18ENSG00000108242CYP2C18chr10:94683621-94736190:+Tbio97.2944
solute carrier family 10 member 7ENSG00000120519SLC10A7chr4:146253975-146521964:-Tdark46.2035
nidogen 2ENSG00000087303NID2chr14:52004803-52069228:-Tbio27.2175
galactosylceramidaseENSG00000054983GALCchr14:87837820-87993665:-Tbio222.174
fibroblast growth factor 21ENSG00000105550FGF21chr19:48755559-48758330:+Tbio387.946
polypeptide N-acetylgalactosaminyltransferase 2ENSG00000143641GALNT2chr1:230057990-230282124:+Tbio44.9655
ATPase phospholipid transporting 8B3ENSG00000130270ATP8B3chr19:1782075-1812276:-Tdark0.916667
coagulation factor II thrombin receptor like 2ENSG00000164220F2RL2chr5:76615482-76623434:-Tbio55.7797
endothelin converting enzyme 2ENSG00000145194ECE2chr3:184249650-184293031:+Tbio28.23

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