PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| Wnt family member 2B | ENSG00000134245 | WNT2B | chr1:112466541-112530165:+ | Tbio | 41.7432 |
| SPARC related modular calcium binding 1 | ENSG00000198732 | SMOC1 | chr14:69854131-70032366:+ | Tbio | 102.067 |
| tubulin epsilon 1 | ENSG00000074935 | TUBE1 | chr6:112070777-112087529:- | Tbio | 51.9429 |
| leukocyte immunoglobulin like receptor B4 | ENSG00000186818 | LILRB4 | chr19:54643889-54670359:+ | Tbio | 56.9219 |
| leukocyte associated immunoglobulin like receptor 1 | ENSG00000167613 | LAIR1 | chr19:54351384-54370558:- | Tbio | 64.5424 |
| ATP binding cassette subfamily A member 7 | ENSG00000064687 | ABCA7 | chr19:1040101-1065572:+ | Tbio | 87.0007 |
| atypical chemokine receptor 3 | ENSG00000144476 | ACKR3 | chr2:236567787-236582358:+ | Tchem | 166.49 |
| sphingosine-1-phosphate receptor 4 | ENSG00000125910 | S1PR4 | chr19:3172346-3180332:+ | Tclin | 31.0322 |
| gremlin 2, DAN family BMP antagonist | ENSG00000180875 | GREM2 | chr1:240489573-240612149:- | Tbio | 7.85852 |
| coiled-coil domain containing 80 | ENSG00000091986 | CCDC80 | chr3:112596794-112649530:- | Tbio | 17.0107 |
| HtrA serine peptidase 3 | ENSG00000170801 | HTRA3 | chr4:8269765-8307111:+ | Tbio | 49.9667 |
| C-X-C motif chemokine ligand 3 | ENSG00000163734 | CXCL3 | chr4:74036589-74038807:- | Tbio | 41.5189 |
| glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | ENSG00000105679 | GAPDHS | chr19:35533412-35545316:+ | Tbio | 27.904 |
| protein tyrosine phosphatase receptor type T | ENSG00000196090 | PTPRT | chr20:42072752-43189970:- | Tbio | 31.8555 |
| histone deacetylase 10 | ENSG00000100429 | HDAC10 | chr22:50245183-50251405:- | Tclin | 31.3709 |
| ADAM metallopeptidase with thrombospondin type 1 motif 8 | ENSG00000134917 | ADAMTS8 | chr11:130404925-130428993:- | Tbio | 15.2913 |
| ATPase plasma membrane Ca2+ transporting 3 | ENSG00000067842 | ATP2B3 | chrX:153517676-153582939:+ | Tbio | 43.2429 |
| KIAA2026 | ENSG00000183354 | KIAA2026 | chr9:5881596-6007901:- | Tdark | 0.1 |
| neurotensin receptor 1 | ENSG00000101188 | NTSR1 | chr20:62708837-62762771:+ | Tchem | 277.421 |
| cathepsin S | ENSG00000163131 | CTSS | chr1:150730196-150765957:- | Tchem | 198.705 |
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