PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
ST6 beta-galactoside alpha-2,6-sialyltransferase 1ENSG00000073849ST6GAL1chr3:186930485-187078553:+Tchem131.092
NBL1, DAN family BMP antagonistENSG00000158747NBL1chr1:19640554-19658456:+Tbio3042.01
vitamin K epoxide reductase complex subunit 1ENSG00000167397VKORC1chr16:31090842-31095980:-Tclin667.151
cell adhesion molecule 3ENSG00000162706CADM3chr1:159171609-159203313:+Tbio15.7894
ADAM metallopeptidase with thrombospondin type 1 motif 12ENSG00000151388ADAMTS12chr5:33523535-33892192:-Tbio22.6499
asporinENSG00000106819ASPNchr9:92456205-92482506:-Tbio137.699
C-X-C motif chemokine receptor 5ENSG00000160683CXCR5chr11:118883766-118897799:+Tbio165.359
actinin alpha 2ENSG00000077522ACTN2chr1:236686454-236764631:+Tbio23.8168
betaine--homocysteine S-methyltransferaseENSG00000145692BHMTchr5:79111779-79132290:+Tchem98.7867
C-type lectin domain family 3 member BENSG00000163815CLEC3Bchr3:45001548-45036071:+Tbio28.8597
carbonic anhydrase 5BENSG00000169239CA5BchrX:15688830-15788409:+Tclin32.9377
endothelin converting enzyme 1ENSG00000117298ECE1chr1:21217247-21345504:-Tchem309.58
unc-51 like autophagy activating kinase 1ENSG00000177169ULK1chr12:131894651-131923167:+Tchem133.608
interleukin 18 receptor 1ENSG00000115604IL18R1chr2:102311529-102398775:+Tbio174.399
serum/glucocorticoid regulated kinase family member 3ENSG00000104205SGK3chr8:66712418-66862022:+Tchem24.2537
transmembrane serine protease 4ENSG00000137648TMPRSS4chr11:118077012-118121890:+Tbio39.0016
ribosomal protein S6 kinase A5ENSG00000100784RPS6KA5chr14:90847862-91060636:-Tchem76.3802
solute carrier family 25 member 6ENSG00000169100SLC25A6chrX:1386152-1392724:-Tbio614.266
enhancer of zeste 1 polycomb repressive complex 2 subunitENSG00000108799EZH1chr17:42700275-42745049:-Tbio20.4534
ADAM metallopeptidase with thrombospondin type 1 motif 14ENSG00000138316ADAMTS14chr10:70672803-70762441:+Tbio10.8923

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