PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
glutamate ionotropic receptor AMPA type subunit 1ENSG00000155511GRIA1chr5:153489615-153813869:+Tclin446.747
hephaestin like 1ENSG00000181333HEPHL1chr11:94021361-94113751:+Tbio0.5
bradykinin receptor B2ENSG00000168398BDKRB2chr14:96204679-96244166:+Tclin346.381
H3.3 histone AENSG00000163041H3F3Achr1:226061851-226072001:+Tbio12.5012
glyoxalase IENSG00000124767GLO1chr6:38675925-38703141:-Tchem503.434
aurora kinase CENSG00000105146AURKCchr19:57230802-57235548:+Tchem58.7571
kynurenine 3-monooxygenaseENSG00000117009KMOchr1:241532134-241595642:+Tchem63.7269
mitogen-activated protein kinase 12ENSG00000188130MAPK12chr22:50245450-50261825:-Tchem43.2697
G protein-coupled receptor kinase 5ENSG00000198873GRK5chr10:119207589-119459742:+Tbio96.5038
aldehyde oxidase 1ENSG00000138356AOX1chr2:200585868-200677064:+Tbio49.8431
Wnt family member 7BENSG00000188064WNT7Bchr22:45920362-45977129:-Tbio28.449
purinergic receptor P2X 1ENSG00000108405P2RX1chr17:3896592-3916500:-Tchem187.381
CD207 moleculeENSG00000116031CD207chr2:70830214-70835822:-Tbio144.395
tachykinin receptor 2ENSG00000075073TACR2chr10:69403903-69416867:-Tchem232.139
neuraminidase 1ENSG00000204386NEU1chr6:31857659-31862906:-Tbio5959.55
NPC1 like intracellular cholesterol transporter 1ENSG00000015520NPC1L1chr7:44512535-44541315:-Tclin163.344
orosomucoid 1ENSG00000229314ORM1chr9:114323056-114326475:+Tbio158.285
ribokinaseENSG00000171174RBKSchr2:27781364-27891098:-Tbio4.83333
solute carrier family 9 member A3ENSG00000066230SLC9A3chr5:473310-524332:-Tbio229.698
male germ cell associated kinaseENSG00000111837MAKchr6:10762723-10838555:-Tchem21.9917

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