PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| interleukin 37 | ENSG00000125571 | IL37 | chr2:112912971-112918882:+ | Tbio | 209.676 |
| lymphocyte antigen 6 family member D | ENSG00000167656 | LY6D | chr8:142784880-142786592:- | Tbio | 42.1976 |
| chondromodulin | ENSG00000136110 | LECT1 | chr13:52703264-52739812:- | Tbio | 57.7142 |
| asialoglycoprotein receptor 1 | ENSG00000141505 | ASGR1 | chr17:7173431-7179564:- | Tbio | 223.568 |
| agouti signaling protein | ENSG00000101440 | ASIP | chr20:34194569-34269344:+ | Tbio | 58.0823 |
| fibromodulin | ENSG00000122176 | FMOD | chr1:203340628-203351489:- | Tbio | 117.745 |
| ribosomal protein S6 kinase A2 | ENSG00000071242 | RPS6KA2 | chr6:166409364-166906451:- | Tchem | 114.284 |
| fibronectin type III domain containing 5 | ENSG00000160097 | FNDC5 | chr1:32862268-32872482:- | Tbio | 242.934 |
| urocortin 2 | ENSG00000145040 | UCN2 | chr3:48561727-48563773:- | Tbio | 60.6596 |
| lysophosphatidic acid receptor 5 | ENSG00000184574 | LPAR5 | chr12:6618835-6636447:- | Tchem | 22.6706 |
| agrin | ENSG00000188157 | AGRN | chr1:1020123-1056118:+ | Tbio | 303.692 |
| receptor interacting serine/threonine kinase 3 | ENSG00000129465 | RIPK3 | chr14:24336021-24340045:- | Tchem | 113.732 |
| tumor suppressor candidate 3 | ENSG00000104723 | TUSC3 | chr8:15417215-15766649:+ | Tbio | 65.8278 |
| insulin like growth factor binding protein acid labile subunit | ENSG00000099769 | IGFALS | chr16:1790413-1794971:- | Tbio | 29.9547 |
| serpin family G member 1 | ENSG00000149131 | SERPING1 | chr11:57597387-57614853:+ | Tbio | 984.859 |
| major histocompatibility complex, class II, DR beta 5 | ENSG00000198502 | HLA-DRB5 | chr6:32517343-32530287:- | Tbio | 268.118 |
| galactokinase 1 | ENSG00000108479 | GALK1 | chr17:75751594-75765711:- | Tbio | 273.592 |
| apolipoprotein C1 | ENSG00000130208 | APOC1 | chr19:44914247-44919349:+ | Tbio | 215.027 |
| receptor interacting serine/threonine kinase 1 | ENSG00000137275 | RIPK1 | chr6:3063991-3115187:+ | Tchem | 481.92 |
| peroxidasin | ENSG00000130508 | PXDN | chr2:1631887-1744852:- | Tbio | 41.4578 |
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