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PDGs

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome

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HGNC Name	Ensembl Gene ID	HGNC Symbol	Genomic Location	TDL	PubTator Score
Fc receptor like 5	ENSG00000143297	FCRL5	chr1:157513377-157552520:-	Tbio	21.7282
apolipoprotein H	ENSG00000091583	APOH	chr17:66212033-66256525:-	Tbio	1178.02
ciliary neurotrophic factor	ENSG00000242689	CNTF	chr11:58622673-58625733:+	Tbio	414.569
2',3'-cyclic nucleotide 3' phosphodiesterase	ENSG00000173786	CNP	chr17:41966741-41977731:+	Tbio	411.502
proprotein convertase subtilisin/kexin type 4	ENSG00000115257	PCSK4	chr19:1481428-1490752:-	Tbio	93.9293
G protein-coupled receptor class C group 5 member A	ENSG00000013588	GPRC5A	chr12:12890782-12917937:+	Tbio	29.1893
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	ENSG00000159131	GART	chr21:33503931-33543491:-	Tchem	102.69
Rho associated coiled-coil containing protein kinase 1	ENSG00000067900	ROCK1	chr18:20946906-21111851:-	Tclin	295.462
double PHD fingers 3	ENSG00000205683	DPF3	chr14:72619296-72894116:-	Tbio	6.21786
dual specificity phosphatase 22	ENSG00000112679	DUSP22	chr6:291630-351355:+	Tbio	29.8854
solute carrier family 8 member A1	ENSG00000183023	SLC8A1	chr2:40097270-40611053:-	Tchem	621.679
Epstein-Barr virus induced 3	ENSG00000105246	EBI3	chr19:4229498-4237531:+	Tbio	40.8043
granulysin	ENSG00000115523	GNLY	chr2:85685175-85698854:+	Tbio	207.466
activated leukocyte cell adhesion molecule	ENSG00000170017	ALCAM	chr3:105366909-105576900:+	Tbio	268.67
deoxyribonuclease 1 like 3	ENSG00000163687	DNASE1L3	chr3:58192257-58214697:-	Tbio	47.6857
spermine oxidase	ENSG00000088826	SMOX	chr20:4120980-4187747:+	Tbio	104.646
toll like receptor 10	ENSG00000174123	TLR10	chr4:38772239-38782990:-	Tbio	61.5657
phenylalanyl-tRNA synthetase 2, mitochondrial	ENSG00000145982	FARS2	chr6:5261044-5771580:+	Tchem	12.7667
ANTXR cell adhesion molecule 2	ENSG00000163297	ANTXR2	chr4:79901149-80125454:-	Tbio	66.9917
tripeptidyl peptidase 1	ENSG00000166340	TPP1	chr11:6612763-6619461:-	Tbio	238.168

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