PDGs

 

The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .

List of the PDGs in the human genome


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HGNC NameEnsembl Gene IDHGNC SymbolGenomic LocationTDLPubTator Score
heat shock protein 90 alpha family class B member 1ENSG00000096384HSP90AB1chr6:44246166-44253888:+Tchem152.174
spindlin family member 4ENSG00000186767SPIN4chrX:63347228-63351344:-Tdark1
milk fat globule EGF and factor V/VIII domain containingENSG00000140545MFGE8chr15:88898683-88913411:-Tbio610.038
F2R like trypsin receptor 1ENSG00000164251F2RL1chr5:76818933-76835315:+Tchem648.853
solute carrier family 6 member 19ENSG00000174358SLC6A19chr5:1201595-1225117:+Tbio28.7603
bone morphogenetic protein 3ENSG00000152785BMP3chr4:81030965-81057531:+Tbio55.4116
chromosome 6 open reading frame 15ENSG00000204542C6orf15chr6:31111223-31112559:-Tdark113.477
solute carrier family 38 member 5ENSG00000017483SLC38A5chrX:48458537-48470256:-Tbio459.763
alcohol dehydrogenase 1A (class I), alpha polypeptideENSG00000187758ADH1Achr4:99276367-99291028:-Tclin171.946
cholinergic receptor nicotinic alpha 1 subunitENSG00000138435CHRNA1chr2:174747592-174764472:-Tclin99.3706
kallikrein related peptidase 5ENSG00000167754KLK5chr19:50943303-50953093:-Tchem77.9317
complement C5a receptor 1ENSG00000197405C5AR1chr19:47290023-47322066:+Tchem1449.19
cathepsin CENSG00000109861CTSCchr11:88293592-88337787:-Tchem287.211
annexin A1ENSG00000135046ANXA1chr9:73151757-73170393:+Tbio533.705
membrane spanning 4-domains A1ENSG00000156738MS4A1chr11:60455752-60470760:+Tclin387.35
opioid related nociceptin receptor 1ENSG00000125510OPRL1chr20:64080173-64100643:+Tchem186.402
inter-alpha-trypsin inhibitor heavy chain 5ENSG00000123243ITIH5chr10:7559270-7666998:-Tbio16.726
potassium voltage-gated channel subfamily A member 3ENSG00000177272KCNA3chr1:110672465-110675033:-Tclin335.914
mitogen-activated protein kinase kinase kinase 9ENSG00000006432MAP3K9chr14:70722526-70809534:-Tchem11.1349
tet methylcytosine dioxygenase 3ENSG00000187605TET3chr2:73986404-74108176:+Tbio33.6542

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