PDGs
The “druggable genome”, a term coined by Hopkins and Groom in 2002(3), defines a subset of genes in the human genome encoding proteins that may be amenable to modulation by drug-like molecules. To define potentially druggable genes (PDGs) in the human genome, we integrated the PDG candidates generated by six independent studies in which the druggable genes were systematically annotated by different strategies at a whole genome level. .
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| HGNC Name | Ensembl Gene ID | HGNC Symbol | Genomic Location | TDL | PubTator Score |
| interleukin 32 | ENSG00000008517 | IL32 | chr16:3065297-3082192:+ | Tbio | 58.2111 |
| nectin cell adhesion molecule 1 | ENSG00000110400 | PVRL1 | chr11:119623408-119729084:- | Tbio | 178.878 |
| hyaluronan and proteoglycan link protein 1 | ENSG00000145681 | HAPLN1 | chr5:83637805-83721613:- | Tbio | 74.6947 |
| G protein-coupled receptor 143 | ENSG00000101850 | GPR143 | chrX:9725346-9786297:- | Tbio | 42.8143 |
| glutamate ionotropic receptor AMPA type subunit 4 | ENSG00000152578 | GRIA4 | chr11:105609994-105982092:+ | Tclin | 107.053 |
| dual oxidase 2 | ENSG00000140279 | DUOX2 | chr15:45092650-45114344:- | Tbio | 153.895 |
| calcium voltage-gated channel auxiliary subunit gamma 8 | ENSG00000142408 | CACNG8 | chr19:53963040-53990215:+ | Tdark | 1.06944 |
| cytochrome P450 family 4 subfamily A member 11 | ENSG00000187048 | CYP4A11 | chr1:46929177-46941484:- | Tbio | 101.336 |
| CD82 molecule | ENSG00000085117 | CD82 | chr11:44564427-44620363:+ | Tbio | 448.484 |
| death associated protein kinase 2 | ENSG00000035664 | DAPK2 | chr15:63907036-64072033:- | Tchem | 29.1223 |
| SUMO peptidase family member, NEDD8 specific | ENSG00000166192 | SENP8 | chr15:72114258-72143688:+ | Tbio | 151.354 |
| tensin 4 | ENSG00000131746 | TNS4 | chr17:40475828-40501597:- | Tbio | 29.6694 |
| chloride channel accessory 2 | ENSG00000137975 | CLCA2 | chr1:86424086-86456558:+ | Tbio | 30.5428 |
| leucine rich alpha-2-glycoprotein 1 | ENSG00000171236 | LRG1 | chr19:4536409-4540474:- | Tbio | 68.9131 |
| FGR proto-oncogene, Src family tyrosine kinase | ENSG00000000938 | FGR | chr1:27612064-27635277:- | Tchem | 142.072 |
| osteoglycin | ENSG00000106809 | OGN | chr9:92383967-92404696:- | Tbio | 292.023 |
| follistatin like 1 | ENSG00000163430 | FSTL1 | chr3:120392293-120451253:- | Tbio | 50.1446 |
| bone morphogenetic protein 8a | ENSG00000183682 | BMP8A | chr1:39491646-39525935:+ | Tbio | 1.27241 |
| ATPase phospholipid transporting 10A (putative) | ENSG00000206190 | ATP10A | chr15:25677273-25865172:- | Tbio | 14.5026 |
| EPH receptor A4 | ENSG00000116106 | EPHA4 | chr2:221418027-221574202:- | Tchem | 99.6465 |
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