Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| KCNS3 | ENSG00000170745 | 0.16 | 0.00 | 1 | 0 |
| GPR37 | ENSG00000170775 | 0.00 | 0.00 | 0 | 0 |
| OR10A4 | ENSG00000170782 | 0.00 | 0.00 | 0 | 0 |
| SDR16C5 | ENSG00000170786 | 0.00 | 0.00 | 0 | 0 |
| OR10A2 | ENSG00000170790 | 0.00 | 0.00 | 0 | 0 |
| FSHR | ENSG00000170820 | 0.00 | 0.00 | 0 | 0 |
| GPR27 | ENSG00000170837 | 0.00 | 0.00 | 0 | 0 |
| MINA | ENSG00000170854 | 0.00 | 0.00 | 0 | 0 |
| TRIAP1 | ENSG00000170855 | 0.00 | 0.30 | 0 | 2 |
| PLA2G1B | ENSG00000170890 | 0.00 | 0.00 | 0 | 0 |
| CYTL1 | ENSG00000170891 | 0.00 | 0.00 | 0 | 0 |
| TRH | ENSG00000170893 | 0.00 | 0.00 | 0 | 0 |
| GSTA4 | ENSG00000170899 | 0.00 | 0.00 | 0 | 0 |
| OR7G3 | ENSG00000170920 | 0.00 | 0.00 | 0 | 0 |
| OR7G2 | ENSG00000170923 | 0.00 | 0.00 | 0 | 0 |
| OR1M1 | ENSG00000170929 | 0.00 | 0.00 | 0 | 0 |
| OR8B12 | ENSG00000170953 | 0.00 | 0.00 | 0 | 0 |
| PLAC1 | ENSG00000170965 | 0.00 | 0.00 | 0 | 0 |
| S1PR1 | ENSG00000170989 | 0.00 | 0.00 | 0 | 0 |
| OR4D5 | ENSG00000171014 | 0.00 | 0.00 | 0 | 0 |
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