Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| ANKK1 | ENSG00000170209 | 0.00 | 0.00 | 0 | 0 |
| ADRA1B | ENSG00000170214 | 0.32 | 0.12 | 1 | 1 |
| FABP6 | ENSG00000170231 | 0.32 | 0.00 | 1 | 0 |
| MRGPRX1 | ENSG00000170255 | 0.00 | 0.00 | 0 | 0 |
| CRTAP | ENSG00000170275 | 0.00 | 0.18 | 0 | 1 |
| FABP4 | ENSG00000170323 | 0.00 | 0.00 | 0 | 0 |
| TMED10 | ENSG00000170348 | 0.00 | 0.50 | 0 | 3 |
| CST5 | ENSG00000170367 | 0.00 | 0.00 | 0 | 0 |
| CST2 | ENSG00000170369 | 0.00 | 0.00 | 0 | 0 |
| CST1 | ENSG00000170373 | 0.00 | 0.00 | 0 | 0 |
| SLC30A1 | ENSG00000170385 | 0.00 | 0.00 | 0 | 0 |
| SDR9C7 | ENSG00000170426 | 0.00 | 0.00 | 0 | 0 |
| CD14 | ENSG00000170458 | 0.00 | 0.00 | 0 | 0 |
| C14orf169 | ENSG00000170468 | 0.00 | 0.44 | 0 | 2 |
| KISS1 | ENSG00000170498 | 0.00 | 0.00 | 0 | 0 |
| ELOVL6 | ENSG00000170522 | 0.00 | 0.00 | 0 | 0 |
| SERPINB9 | ENSG00000170542 | 0.22 | 0.00 | 1 | 0 |
| OR9K2 | ENSG00000170605 | 0.00 | 0.00 | 0 | 0 |
| OR10A3 | ENSG00000170683 | 0.00 | 0.00 | 0 | 0 |
| OR5E1P | ENSG00000170688 | 0.00 | 0.00 | 0 | 0 |
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