Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| MFSD8 | ENSG00000164073 | 0.00 | 0.00 | 0 | 0 |
| CAMKV | ENSG00000164076 | 0.00 | 0.00 | 0 | 0 |
| GRM2 | ENSG00000164082 | 0.00 | 0.00 | 0 | 0 |
| ETNPPL | ENSG00000164089 | 0.00 | 0.00 | 0 | 0 |
| PRSS12 | ENSG00000164099 | 0.00 | 0.00 | 0 | 0 |
| HMGB2 | ENSG00000164104 | 0.00 | 0.23 | 0 | 2 |
| SCRG1 | ENSG00000164106 | 0.00 | 0.00 | 0 | 0 |
| HPGD | ENSG00000164120 | 0.00 | 0.00 | 0 | 0 |
| IL15 | ENSG00000164136 | 0.00 | 0.00 | 0 | 0 |
| PRMT9 | ENSG00000164169 | 0.00 | 0.00 | 0 | 0 |
| SLC25A46 | ENSG00000164209 | 0.00 | 0.13 | 0 | 1 |
| F2RL2 | ENSG00000164220 | 0.00 | 0.00 | 0 | 0 |
| F2RL1 | ENSG00000164251 | 0.00 | 0.85 | 0 | 2 |
| AGGF1 | ENSG00000164252 | 0.00 | 0.85 | 0 | 2 |
| PRDM9 | ENSG00000164256 | 0.00 | 0.00 | 0 | 0 |
| SCGB3A2 | ENSG00000164265 | 0.00 | 0.00 | 0 | 0 |
| SPINK1 | ENSG00000164266 | 0.00 | 0.00 | 0 | 0 |
| ESM1 | ENSG00000164283 | 0.00 | 0.00 | 0 | 0 |
| ARSK | ENSG00000164291 | 0.00 | 0.22 | 0 | 2 |
| GPX8 | ENSG00000164294 | 0.00 | 0.00 | 0 | 0 |
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