Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 84 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| CXCL1 | ENSG00000163739 | 0.00 | 0.00 | 0 | 0 |
| PLSCR2 | ENSG00000163746 | 0.00 | 0.00 | 0 | 0 |
| RYK | ENSG00000163785 | 0.00 | 0.00 | 0 | 0 |
| UCN | ENSG00000163794 | 0.00 | 0.00 | 0 | 0 |
| TGM4 | ENSG00000163810 | 0.00 | 0.00 | 0 | 0 |
| CDCP1 | ENSG00000163814 | 0.00 | 0.18 | 0 | 1 |
| CLEC3B | ENSG00000163815 | 0.00 | 0.00 | 0 | 0 |
| SLC6A20 | ENSG00000163817 | 0.00 | 0.18 | 0 | 1 |
| CCR1 | ENSG00000163823 | 0.00 | 0.00 | 0 | 0 |
| LIPH | ENSG00000163898 | 0.00 | 0.00 | 0 | 0 |
| RHO | ENSG00000163914 | 0.00 | 0.00 | 0 | 0 |
| LRPAP1 | ENSG00000163956 | 0.00 | 0.00 | 0 | 0 |
| MFI2 | ENSG00000163975 | 0.00 | 0.12 | 0 | 1 |
| OTOP1 | ENSG00000163982 | 0.00 | 0.00 | 0 | 0 |
| ERMAP | ENSG00000164010 | 0.11 | 0.00 | 1 | 0 |
| AIMP1 | ENSG00000164022 | 0.00 | 0.13 | 0 | 1 |
| METAP1 | ENSG00000164024 | 0.00 | 0.00 | 0 | 0 |
| BDH2 | ENSG00000164039 | 0.00 | 0.13 | 0 | 1 |
| CAMP | ENSG00000164047 | 0.00 | 0.00 | 0 | 0 |
| APEH | ENSG00000164062 | 0.00 | 0.84 | 0 | 5 |
|
Showing page 84 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.