Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR7G1 | ENSG00000161807 | 0.00 | 0.00 | 0 | 0 |
| ALOX15 | ENSG00000161905 | 0.00 | 0.00 | 0 | 0 |
| CXCL16 | ENSG00000161921 | 0.00 | 0.12 | 0 | 1 |
| TNFSF13 | ENSG00000161955 | 0.00 | 0.16 | 0 | 1 |
| NTN3 | ENSG00000162068 | 0.00 | 0.00 | 0 | 0 |
| SLC25A45 | ENSG00000162241 | 0.00 | 0.00 | 0 | 0 |
| CYP4A22 | ENSG00000162365 | 0.00 | 0.00 | 0 | 0 |
| SLC1A7 | ENSG00000162383 | 0.00 | 0.00 | 0 | 0 |
| SLC45A1 | ENSG00000162426 | 0.00 | 1.22 | 0 | 2 |
| CTRC | ENSG00000162438 | 0.00 | 0.00 | 0 | 0 |
| RBP7 | ENSG00000162444 | 0.00 | 0.00 | 0 | 0 |
| SLC25A34 | ENSG00000162461 | 0.00 | 0.00 | 0 | 0 |
| AKR7A3 | ENSG00000162482 | 0.00 | 0.55 | 0 | 3 |
| DRAXIN | ENSG00000162490 | 0.00 | 0.00 | 0 | 0 |
| DHRS3 | ENSG00000162496 | 0.00 | 0.53 | 0 | 3 |
| MATN1 | ENSG00000162510 | 0.00 | 0.00 | 0 | 0 |
| TSSK3 | ENSG00000162526 | 0.00 | 0.00 | 0 | 0 |
| WNT4 | ENSG00000162552 | 0.00 | 0.23 | 0 | 2 |
| TM2D1 | ENSG00000162604 | 0.00 | 0.00 | 0 | 0 |
| ADGRL4 | ENSG00000162618 | 0.00 | 0.00 | 0 | 0 |
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