Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| GPR6 | ENSG00000146360 | 0.00 | 0.00 | 0 | 0 |
| TAAR2 | ENSG00000146378 | 0.00 | 0.00 | 0 | 0 |
| TAAR6 | ENSG00000146383 | 0.00 | 0.00 | 0 | 0 |
| TAAR8 | ENSG00000146385 | 0.00 | 0.00 | 0 | 0 |
| TAAR1 | ENSG00000146399 | 0.00 | 0.00 | 0 | 0 |
| VIP | ENSG00000146469 | 0.00 | 0.00 | 0 | 0 |
| IGFBP1 | ENSG00000146678 | 0.00 | 0.00 | 0 | 0 |
| SSC4D | ENSG00000146700 | 0.00 | 0.00 | 0 | 0 |
| SLC12A9 | ENSG00000146828 | 0.00 | 0.00 | 0 | 0 |
| TMEM27 | ENSG00000147003 | 0.00 | 0.00 | 0 | 0 |
| SPIN2A | ENSG00000147059 | 0.00 | 0.00 | 0 | 0 |
| HDAC8 | ENSG00000147099 | 0.00 | 0.00 | 0 | 0 |
| GPR174 | ENSG00000147138 | 0.00 | 0.00 | 0 | 0 |
| EBP | ENSG00000147155 | 0.00 | 0.00 | 0 | 0 |
| IL2RG | ENSG00000147168 | 0.00 | 0.00 | 0 | 0 |
| GPR119 | ENSG00000147262 | 0.00 | 0.00 | 0 | 0 |
| NSDHL | ENSG00000147383 | 0.42 | 0.00 | 3 | 0 |
| GNRH1 | ENSG00000147437 | 0.00 | 0.49 | 0 | 3 |
| SLC25A37 | ENSG00000147454 | 0.00 | 0.91 | 0 | 6 |
| CRH | ENSG00000147571 | 0.00 | 0.00 | 0 | 0 |
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