Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 66 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| CPO | ENSG00000144410 | 0.00 | 0.00 | 0 | 0 |
| CTDSP1 | ENSG00000144579 | 0.00 | 0.95 | 0 | 5 |
| ACKR2 | ENSG00000144648 | 0.00 | 0.00 | 0 | 0 |
| SLC25A38 | ENSG00000144659 | 0.00 | 0.18 | 0 | 1 |
| SLC22A14 | ENSG00000144671 | 0.00 | 0.00 | 0 | 0 |
| SLC25A26 | ENSG00000144741 | 0.00 | 0.00 | 0 | 0 |
| ADGRG7 | ENSG00000144820 | 0.00 | 0.00 | 0 | 0 |
| BOC | ENSG00000144857 | 0.00 | 0.00 | 0 | 0 |
| UCN2 | ENSG00000145040 | 0.00 | 0.13 | 0 | 1 |
| VPRBP | ENSG00000145041 | 0.00 | 0.88 | 0 | 5 |
| MANF | ENSG00000145050 | 0.00 | 0.69 | 0 | 4 |
| SLIT2 | ENSG00000145147 | 0.00 | 0.00 | 0 | 0 |
| ECE2 | ENSG00000145194 | 0.39 | 0.10 | 2 | 1 |
| SLC26A1 | ENSG00000145217 | 0.52 | 0.00 | 2 | 0 |
| SLC10A4 | ENSG00000145248 | 0.00 | 0.00 | 0 | 0 |
| SLC10A6 | ENSG00000145283 | 0.00 | 0.00 | 0 | 0 |
| SNCA | ENSG00000145335 | 0.00 | 0.00 | 0 | 0 |
| FABP2 | ENSG00000145384 | 0.00 | 0.00 | 0 | 0 |
| CCNA2 | ENSG00000145386 | 0.00 | 0.00 | 0 | 0 |
| SFRP2 | ENSG00000145423 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 66 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.