Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 63 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| IL19 | ENSG00000142224 | 0.00 | 0.00 | 0 | 0 |
| SLC6A3 | ENSG00000142319 | 0.00 | 0.00 | 0 | 0 |
| RNPEPL1 | ENSG00000142327 | 0.00 | 1.97 | 0 | 9 |
| CAPN10 | ENSG00000142330 | 0.00 | 1.97 | 0 | 9 |
| PSMB6 | ENSG00000142507 | 0.00 | 0.12 | 0 | 1 |
| GPR32 | ENSG00000142511 | 0.00 | 0.00 | 0 | 0 |
| SIGLEC10 | ENSG00000142512 | 0.00 | 0.00 | 0 | 0 |
| PTH2 | ENSG00000142538 | 0.00 | 0.00 | 0 | 0 |
| PADI3 | ENSG00000142619 | 0.00 | 0.12 | 0 | 1 |
| PLK4 | ENSG00000142731 | 0.00 | 0.00 | 0 | 0 |
| FCN3 | ENSG00000142748 | 0.00 | 0.00 | 0 | 0 |
| CYR61 | ENSG00000142871 | 0.00 | 0.00 | 0 | 0 |
| TINAGL1 | ENSG00000142910 | 0.00 | 0.00 | 0 | 0 |
| AZIN2 | ENSG00000142920 | 0.00 | 0.00 | 0 | 0 |
| CYP4B1 | ENSG00000142973 | 0.00 | 0.00 | 0 | 0 |
| SLC44A3 | ENSG00000143036 | 0.00 | 0.11 | 0 | 1 |
| KCNA10 | ENSG00000143105 | 0.00 | 0.00 | 0 | 0 |
| PSMA5 | ENSG00000143106 | 0.00 | 0.46 | 0 | 2 |
| CD53 | ENSG00000143119 | 0.00 | 0.24 | 0 | 2 |
| PROK1 | ENSG00000143125 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 63 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.