Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| CD27 | ENSG00000139193 | 0.00 | 0.00 | 0 | 0 |
| RBP5 | ENSG00000139194 | 0.00 | 0.00 | 0 | 0 |
| INHBE | ENSG00000139269 | 0.00 | 0.00 | 0 | 0 |
| PTPRQ | ENSG00000139304 | 0.00 | 0.00 | 0 | 0 |
| DUSP6 | ENSG00000139318 | 0.00 | 0.00 | 0 | 0 |
| LUM | ENSG00000139329 | 0.00 | 0.00 | 0 | 0 |
| KERA | ENSG00000139330 | 0.00 | 0.00 | 0 | 0 |
| SLC46A3 | ENSG00000139508 | 0.00 | 0.00 | 0 | 0 |
| RDH16 | ENSG00000139547 | 0.00 | 0.00 | 0 | 0 |
| DHH | ENSG00000139549 | 0.00 | 0.00 | 0 | 0 |
| GPR84 | ENSG00000139572 | 0.00 | 0.00 | 0 | 0 |
| NPFF | ENSG00000139574 | 0.00 | 0.00 | 0 | 0 |
| CELA1 | ENSG00000139610 | 0.00 | 0.00 | 0 | 0 |
| SSTR1 | ENSG00000139874 | 0.00 | 0.00 | 0 | 0 |
| CBLN3 | ENSG00000139899 | 0.00 | 0.00 | 0 | 0 |
| TSSK4 | ENSG00000139908 | 0.00 | 0.00 | 0 | 0 |
| TMX1 | ENSG00000139921 | 0.00 | 0.00 | 0 | 0 |
| ADAM21 | ENSG00000139985 | 0.00 | 0.00 | 0 | 0 |
| RDH12 | ENSG00000139988 | 0.00 | 0.00 | 0 | 0 |
| KCNH5 | ENSG00000140015 | 0.00 | 0.00 | 0 | 0 |
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