Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 6 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| ITIH1 | ENSG00000055957 | 0.00 | 0.00 | 0 | 0 |
| IL17RB | ENSG00000056736 | 0.00 | 0.50 | 0 | 3 |
| SERPINB3 | ENSG00000057149 | 0.00 | 0.00 | 0 | 0 |
| F7 | ENSG00000057593 | 0.29 | 0.00 | 1 | 0 |
| RIOK2 | ENSG00000058729 | 0.00 | 0.12 | 0 | 1 |
| SLC2A3 | ENSG00000059804 | 0.57 | 0.00 | 1 | 0 |
| GUCY1B3 | ENSG00000061918 | 0.00 | 0.00 | 0 | 0 |
| ARSF | ENSG00000062096 | 0.00 | 0.00 | 0 | 0 |
| POLD1 | ENSG00000062822 | 0.00 | 0.45 | 0 | 2 |
| SLC6A16 | ENSG00000063127 | 0.00 | 0.00 | 0 | 0 |
| SPHK2 | ENSG00000063176 | 0.00 | 0.55 | 0 | 2 |
| GPC1 | ENSG00000063660 | 0.00 | 1.72 | 0 | 8 |
| WISP2 | ENSG00000064205 | 0.00 | 0.00 | 0 | 0 |
| HIPK2 | ENSG00000064393 | 0.00 | 0.00 | 0 | 0 |
| LPAR2 | ENSG00000064547 | 0.00 | 0.00 | 0 | 0 |
| CTSA | ENSG00000064601 | 0.13 | 0.00 | 1 | 0 |
| OAT | ENSG00000065154 | 0.00 | 0.38 | 0 | 3 |
| KARS | ENSG00000065427 | 0.00 | 0.19 | 0 | 1 |
| PRKCQ | ENSG00000065675 | 0.17 | 0.00 | 1 | 0 |
| SLC9A7 | ENSG00000065923 | 0.10 | 0.00 | 1 | 0 |
|
Showing page 6 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.