Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| CAPN11 | ENSG00000137225 | 0.00 | 0.00 | 0 | 0 |
| TINAG | ENSG00000137251 | 0.00 | 0.00 | 0 | 0 |
| TUBB2B | ENSG00000137285 | 0.00 | 0.14 | 0 | 1 |
| TCF19 | ENSG00000137310 | 0.00 | 0.00 | 0 | 0 |
| ATAT1 | ENSG00000137343 | 0.20 | 0.00 | 1 | 0 |
| TPMT | ENSG00000137364 | 0.00 | 0.29 | 0 | 2 |
| CLPS | ENSG00000137392 | 0.00 | 0.00 | 0 | 0 |
| MTCH1 | ENSG00000137409 | 0.00 | 0.00 | 0 | 0 |
| FGFBP1 | ENSG00000137440 | 0.00 | 0.00 | 0 | 0 |
| FGFBP2 | ENSG00000137441 | 0.00 | 0.00 | 0 | 0 |
| TLR2 | ENSG00000137462 | 0.00 | 0.00 | 0 | 0 |
| IL18BP | ENSG00000137496 | 0.91 | 0.00 | 1 | 0 |
| PI15 | ENSG00000137558 | 0.00 | 0.00 | 0 | 0 |
| GGH | ENSG00000137563 | 0.53 | 0.00 | 3 | 0 |
| MMP7 | ENSG00000137673 | 0.30 | 0.00 | 1 | 0 |
| SLC37A4 | ENSG00000137700 | 0.00 | 0.63 | 0 | 3 |
| FXYD2 | ENSG00000137731 | 0.00 | 0.23 | 0 | 1 |
| TMPRSS13 | ENSG00000137747 | 0.00 | 0.23 | 0 | 1 |
| CASP1 | ENSG00000137752 | 0.00 | 0.00 | 0 | 0 |
| CASP5 | ENSG00000137757 | 0.00 | 0.00 | 0 | 0 |
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