Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 50 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| DDC | ENSG00000132437 | 0.00 | 0.00 | 0 | 0 |
| ENAM | ENSG00000132464 | 0.00 | 0.00 | 0 | 0 |
| JCHAIN | ENSG00000132465 | 0.00 | 0.00 | 0 | 0 |
| H3F3B | ENSG00000132475 | 1.33 | 0.00 | 6 | 0 |
| CLEC10A | ENSG00000132514 | 0.00 | 0.14 | 0 | 1 |
| GUCY2D | ENSG00000132518 | 0.00 | 0.00 | 0 | 0 |
| SDF2 | ENSG00000132581 | 0.00 | 0.00 | 0 | 0 |
| SNAP25 | ENSG00000132639 | 0.00 | 0.00 | 0 | 0 |
| SSTR4 | ENSG00000132671 | 0.00 | 0.00 | 0 | 0 |
| RHBG | ENSG00000132677 | 0.00 | 0.00 | 0 | 0 |
| CRP | ENSG00000132693 | 0.00 | 0.00 | 0 | 0 |
| APCS | ENSG00000132703 | 0.00 | 0.00 | 0 | 0 |
| FCRL2 | ENSG00000132704 | 0.00 | 0.00 | 0 | 0 |
| BHMT2 | ENSG00000132840 | 0.00 | 0.00 | 0 | 0 |
| ANGPTL3 | ENSG00000132855 | 0.00 | 0.00 | 0 | 0 |
| NMUR2 | ENSG00000132911 | 0.00 | 0.00 | 0 | 0 |
| PDE6A | ENSG00000132915 | 0.00 | 0.00 | 0 | 0 |
| RNF17 | ENSG00000132972 | 0.00 | 0.00 | 0 | 0 |
| GPR12 | ENSG00000132975 | 0.00 | 0.00 | 0 | 0 |
| PIK3C2B | ENSG00000133056 | 0.35 | 0.00 | 2 | 0 |
|
Showing page 50 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.