Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OR11H1 | ENSG00000130538 | 0.00 | 0.00 | 0 | 0 |
| FIBCD1 | ENSG00000130720 | 0.00 | 0.00 | 0 | 0 |
| ANGPTL6 | ENSG00000130812 | 0.00 | 0.00 | 0 | 0 |
| DUSP9 | ENSG00000130829 | 0.00 | 0.00 | 0 | 0 |
| PKDREJ | ENSG00000130943 | 0.00 | 0.00 | 0 | 0 |
| HABP4 | ENSG00000130956 | 0.00 | 0.15 | 0 | 1 |
| SLC35D2 | ENSG00000130958 | 0.00 | 0.00 | 0 | 0 |
| LILRB2 | ENSG00000131042 | 0.00 | 0.17 | 0 | 1 |
| BPIFA2 | ENSG00000131050 | 0.00 | 0.00 | 0 | 0 |
| BPIFA3 | ENSG00000131059 | 0.00 | 0.00 | 0 | 0 |
| GGT7 | ENSG00000131067 | 0.00 | 0.00 | 0 | 0 |
| DEFB118 | ENSG00000131068 | 0.00 | 0.00 | 0 | 0 |
| PYY | ENSG00000131096 | 0.00 | 0.00 | 0 | 0 |
| CCL25 | ENSG00000131142 | 0.00 | 0.00 | 0 | 0 |
| COX7B | ENSG00000131174 | 0.00 | 0.00 | 0 | 0 |
| ADGRE3 | ENSG00000131355 | 0.00 | 0.00 | 0 | 0 |
| CAPN7 | ENSG00000131375 | 0.00 | 0.36 | 0 | 2 |
| NAPSB | ENSG00000131401 | 0.00 | 0.00 | 0 | 0 |
| NR1H2 | ENSG00000131408 | 0.23 | 0.45 | 1 | 2 |
| LRRC4B | ENSG00000131409 | 0.00 | 0.00 | 0 | 0 |
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