Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| OMG | ENSG00000126861 | 0.00 | 0.64 | 0 | 2 |
| AVPR2 | ENSG00000126895 | 0.00 | 0.00 | 0 | 0 |
| SLC10A3 | ENSG00000126903 | 1.38 | 0.00 | 6 | 0 |
| MAP2K2 | ENSG00000126934 | 0.00 | 1.15 | 0 | 3 |
| OMD | ENSG00000127083 | 0.00 | 0.00 | 0 | 0 |
| EDN2 | ENSG00000127129 | 0.00 | 0.00 | 0 | 0 |
| IL22 | ENSG00000127318 | 0.00 | 0.00 | 0 | 0 |
| TAS2R3 | ENSG00000127362 | 0.00 | 0.00 | 0 | 0 |
| TAS2R4 | ENSG00000127364 | 0.00 | 0.00 | 0 | 0 |
| TAS2R5 | ENSG00000127366 | 0.10 | 0.00 | 1 | 0 |
| TRPV5 | ENSG00000127412 | 0.00 | 0.00 | 0 | 0 |
| FGFRL1 | ENSG00000127418 | 0.42 | 0.00 | 1 | 0 |
| PIN1 | ENSG00000127445 | 0.00 | 0.00 | 0 | 0 |
| PLA2G5 | ENSG00000127472 | 0.00 | 0.31 | 0 | 2 |
| ADGRE2 | ENSG00000127507 | 0.00 | 0.00 | 0 | 0 |
| OR7A10 | ENSG00000127515 | 0.00 | 0.00 | 0 | 0 |
| SLC35E1 | ENSG00000127526 | 0.24 | 0.00 | 1 | 0 |
| OR7C2 | ENSG00000127529 | 0.00 | 0.00 | 0 | 0 |
| OR7C1 | ENSG00000127530 | 0.00 | 0.00 | 0 | 0 |
| F2RL3 | ENSG00000127533 | 0.00 | 0.00 | 0 | 0 |
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