Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| DEFB126 | ENSG00000125788 | 0.33 | 0.00 | 1 | 0 |
| CD93 | ENSG00000125810 | 0.00 | 0.00 | 0 | 0 |
| CST8 | ENSG00000125815 | 0.00 | 0.00 | 0 | 0 |
| TMX4 | ENSG00000125827 | 0.00 | 0.00 | 0 | 0 |
| CST11 | ENSG00000125831 | 0.00 | 0.00 | 0 | 0 |
| GFRA4 | ENSG00000125861 | 0.00 | 0.00 | 0 | 0 |
| OTOR | ENSG00000125879 | 0.00 | 0.00 | 0 | 0 |
| S1PR4 | ENSG00000125910 | 0.00 | 0.14 | 0 | 1 |
| GRPR | ENSG00000126010 | 0.00 | 0.00 | 0 | 0 |
| PSMB2 | ENSG00000126067 | 0.00 | 0.00 | 0 | 0 |
| PROZ | ENSG00000126231 | 0.29 | 0.00 | 1 | 0 |
| SLURP1 | ENSG00000126233 | 0.00 | 0.00 | 0 | 0 |
| GPR42 | ENSG00000126251 | 0.00 | 0.00 | 0 | 0 |
| FFAR2 | ENSG00000126262 | 0.00 | 0.00 | 0 | 0 |
| FFAR1 | ENSG00000126266 | 0.00 | 0.00 | 0 | 0 |
| STATH | ENSG00000126549 | 0.00 | 0.00 | 0 | 0 |
| HTN1 | ENSG00000126550 | 0.00 | 0.00 | 0 | 0 |
| WNK4 | ENSG00000126562 | 0.00 | 0.00 | 0 | 0 |
| CFP | ENSG00000126759 | 0.00 | 0.00 | 0 | 0 |
| PRDM7 | ENSG00000126856 | 0.00 | 0.00 | 0 | 0 |
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