Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| EPX | ENSG00000121053 | 0.00 | 0.00 | 0 | 0 |
| TAS2R8 | ENSG00000121314 | 0.00 | 0.00 | 0 | 0 |
| TAS2R10 | ENSG00000121318 | 0.00 | 0.00 | 0 | 0 |
| PRB2 | ENSG00000121335 | 0.00 | 0.00 | 0 | 0 |
| IAPP | ENSG00000121351 | 0.00 | 0.00 | 0 | 0 |
| KCNJ8 | ENSG00000121361 | 0.62 | 0.00 | 1 | 0 |
| TAS2R7 | ENSG00000121377 | 0.00 | 0.00 | 0 | 0 |
| BCL2L14 | ENSG00000121380 | 0.00 | 0.00 | 0 | 0 |
| TAS2R9 | ENSG00000121381 | 0.00 | 0.00 | 0 | 0 |
| CRY2 | ENSG00000121671 | 0.31 | 0.00 | 2 | 0 |
| FABP3 | ENSG00000121769 | 0.00 | 0.00 | 0 | 0 |
| CCR2 | ENSG00000121807 | 0.00 | 0.00 | 0 | 0 |
| GHSR | ENSG00000121853 | 0.00 | 0.00 | 0 | 0 |
| CPXM2 | ENSG00000121898 | 0.00 | 0.11 | 0 | 1 |
| ADORA3 | ENSG00000121933 | 0.00 | 0.00 | 0 | 0 |
| SV2C | ENSG00000122012 | 0.00 | 0.00 | 0 | 0 |
| XPNPEP2 | ENSG00000122121 | 0.00 | 0.00 | 0 | 0 |
| OCRL | ENSG00000122126 | 0.00 | 0.00 | 0 | 0 |
| OBP2A | ENSG00000122136 | 0.00 | 0.24 | 0 | 1 |
| PLG | ENSG00000122194 | 0.00 | 0.00 | 0 | 0 |
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