Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| CA7 | ENSG00000168748 | 0.00 | 0.00 | 0 | 0 |
| CELA2B | ENSG00000215704 | 0.00 | 0.00 | 0 | 0 |
| MAP3K19 | ENSG00000176601 | 0.00 | 0.00 | 0 | 0 |
| CACNA1F | ENSG00000102001 | 0.00 | 0.00 | 0 | 0 |
| HTR4 | ENSG00000164270 | 0.00 | 0.00 | 0 | 0 |
| WNT8A | ENSG00000061492 | 0.00 | 0.00 | 0 | 0 |
| IMPG2 | ENSG00000081148 | 0.00 | 0.00 | 0 | 0 |
| PDE6C | ENSG00000095464 | 0.00 | 0.00 | 0 | 0 |
| PNLIPRP1 | ENSG00000187021 | 0.00 | 0.00 | 0 | 0 |
| IL17A | ENSG00000112115 | 0.00 | 0.00 | 0 | 0 |
| CHIA | ENSG00000134216 | 0.00 | 0.00 | 0 | 0 |
| GLIPR1L1 | ENSG00000173401 | 0.00 | 0.00 | 0 | 0 |
| OPTC | ENSG00000188770 | 0.00 | 0.00 | 0 | 0 |
| SMYD1 | ENSG00000115593 | 0.00 | 0.00 | 0 | 0 |
| BPI | ENSG00000101425 | 0.00 | 0.00 | 0 | 0 |
| MLNR | ENSG00000102539 | 0.00 | 0.00 | 0 | 0 |
| ADAM32 | ENSG00000197140 | 0.00 | 0.00 | 0 | 0 |
| CEACAM3 | ENSG00000170956 | 0.00 | 0.00 | 0 | 0 |
| LIPJ | ENSG00000204022 | 0.00 | 0.00 | 0 | 0 |
| LIPI | ENSG00000188992 | 0.00 | 0.00 | 0 | 0 |
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