Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| TPH2 | ENSG00000139287 | 0.00 | 0.00 | 0 | 0 |
| KCNH7 | ENSG00000184611 | 0.00 | 0.00 | 0 | 0 |
| PM20D1 | ENSG00000162877 | 0.00 | 0.00 | 0 | 0 |
| FBP2 | ENSG00000130957 | 0.00 | 0.00 | 0 | 0 |
| GLRA2 | ENSG00000101958 | 0.00 | 0.00 | 0 | 0 |
| TSPEAR | ENSG00000175894 | 0.00 | 0.00 | 0 | 0 |
| ADAMTS20 | ENSG00000173157 | 0.00 | 0.00 | 0 | 0 |
| PRSS55 | ENSG00000184647 | 0.00 | 0.00 | 0 | 0 |
| GRM7 | ENSG00000196277 | 0.00 | 0.00 | 0 | 0 |
| FGF3 | ENSG00000186895 | 0.00 | 0.00 | 0 | 0 |
| GP5 | ENSG00000178732 | 0.00 | 0.00 | 0 | 0 |
| CACNA1S | ENSG00000081248 | 0.00 | 0.00 | 0 | 0 |
| METTL21C | ENSG00000139780 | 0.00 | 0.00 | 0 | 0 |
| MRGPRX3 | ENSG00000179826 | 0.00 | 0.00 | 0 | 0 |
| WFIKKN2 | ENSG00000173714 | 0.00 | 0.00 | 0 | 0 |
| CA6 | ENSG00000131686 | 0.00 | 0.00 | 0 | 0 |
| TAS1R1 | ENSG00000173662 | 0.00 | 0.00 | 0 | 0 |
| TMPRSS15 | ENSG00000154646 | 0.00 | 0.00 | 0 | 0 |
| TRPM6 | ENSG00000119121 | 0.00 | 0.00 | 0 | 0 |
| TTN | ENSG00000155657 | 0.00 | 0.00 | 0 | 0 |
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