Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| PRL | ENSG00000172179 | 0.00 | 0.00 | 0 | 0 |
| USP47 | ENSG00000170242 | 0.00 | 0.00 | 0 | 0 |
| SLC25A31 | ENSG00000151475 | 0.00 | 0.00 | 0 | 0 |
| PIK3C2A | ENSG00000011405 | 0.00 | 0.00 | 0 | 0 |
| SLC11A2 | ENSG00000110911 | 0.00 | 0.00 | 0 | 0 |
| HSD3B2 | ENSG00000203859 | 0.00 | 0.00 | 0 | 0 |
| LPAR4 | ENSG00000147145 | 0.00 | 0.00 | 0 | 0 |
| CELA3B | ENSG00000219073 | 0.00 | 0.00 | 0 | 0 |
| APOA5 | ENSG00000110243 | 0.00 | 0.00 | 0 | 0 |
| SGPL1 | ENSG00000166224 | 0.00 | 0.00 | 0 | 0 |
| CYP2A7 | ENSG00000198077 | 0.00 | 0.00 | 0 | 0 |
| BTN2A1 | ENSG00000112763 | 0.00 | 0.00 | 0 | 0 |
| PPIG | ENSG00000138398 | 0.00 | 0.00 | 0 | 0 |
| KLHL20 | ENSG00000076321 | 0.00 | 0.00 | 0 | 0 |
| MMP26 | ENSG00000167346 | 0.00 | 0.00 | 0 | 0 |
| C8A | ENSG00000157131 | 0.00 | 0.00 | 0 | 0 |
| SLC25A17 | ENSG00000100372 | 0.00 | 0.00 | 0 | 0 |
| HCRTR1 | ENSG00000121764 | 0.00 | 0.00 | 0 | 0 |
| GPD2 | ENSG00000115159 | 0.00 | 0.00 | 0 | 0 |
| ASIC2 | ENSG00000108684 | 0.00 | 0.00 | 0 | 0 |
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