Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
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| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| ASIC1 | ENSG00000110881 | 0.00 | 0.00 | 0 | 0 |
| DAO | ENSG00000110887 | 0.00 | 0.00 | 0 | 0 |
| IL23A | ENSG00000110944 | 0.00 | 0.00 | 0 | 0 |
| ATP5B | ENSG00000110955 | 0.00 | 0.00 | 0 | 0 |
| SLC6A12 | ENSG00000111181 | 0.47 | 0.00 | 1 | 0 |
| PRR4 | ENSG00000111215 | 0.55 | 0.16 | 1 | 1 |
| KCNA1 | ENSG00000111262 | 0.00 | 0.00 | 0 | 0 |
| GPRC5D | ENSG00000111291 | 0.00 | 0.00 | 0 | 0 |
| MGP | ENSG00000111341 | 0.00 | 0.00 | 0 | 0 |
| ENDOU | ENSG00000111405 | 0.00 | 0.00 | 0 | 0 |
| FZD10 | ENSG00000111432 | 0.00 | 0.00 | 0 | 0 |
| ADGRD1 | ENSG00000111452 | 0.00 | 0.11 | 0 | 1 |
| IL26 | ENSG00000111536 | 0.00 | 0.00 | 0 | 0 |
| IFNG | ENSG00000111537 | 0.00 | 0.00 | 0 | 0 |
| LPCAT3 | ENSG00000111684 | 0.60 | 0.00 | 1 | 0 |
| SLCO1B3 | ENSG00000111700 | 0.00 | 0.00 | 0 | 0 |
| PRKAB1 | ENSG00000111725 | 0.00 | 0.17 | 0 | 1 |
| RAB35 | ENSG00000111737 | 0.00 | 0.17 | 0 | 1 |
| KLRB1 | ENSG00000111796 | 0.00 | 0.00 | 0 | 0 |
| BTN3A3 | ENSG00000111801 | 0.00 | 0.00 | 0 | 0 |
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