Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 268 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| CACNA1A | ENSG00000141837 | 0.00 | 0.00 | 0 | 0 |
| STAMBP | ENSG00000124356 | 0.00 | 0.00 | 0 | 0 |
| SLC17A1 | ENSG00000124568 | 0.00 | 0.00 | 0 | 0 |
| CSK | ENSG00000103653 | 0.12 | 0.00 | 1 | 0 |
| PRMT7 | ENSG00000132600 | 0.31 | 0.48 | 2 | 2 |
| LRRTM3 | ENSG00000198739 | 0.00 | 0.00 | 0 | 0 |
| PRSS57 | ENSG00000185198 | 0.00 | 0.00 | 0 | 0 |
| HIF1A | ENSG00000100644 | 0.00 | 0.25 | 0 | 1 |
| RHBDL3 | ENSG00000141314 | 0.00 | 0.00 | 0 | 0 |
| IL18R1 | ENSG00000115604 | 0.00 | 0.00 | 0 | 0 |
| AGTPBP1 | ENSG00000135049 | 0.00 | 0.15 | 0 | 1 |
| ALPK1 | ENSG00000073331 | 0.00 | 0.00 | 0 | 0 |
| CSNK1G2 | ENSG00000133275 | 0.00 | 0.96 | 0 | 2 |
| HCAR1 | ENSG00000196917 | 0.00 | 0.00 | 0 | 0 |
| GRM1 | ENSG00000152822 | 0.00 | 0.00 | 0 | 0 |
| MBNL1 | ENSG00000152601 | 0.00 | 0.00 | 0 | 0 |
| GFRA3 | ENSG00000146013 | 0.00 | 0.00 | 0 | 0 |
| OXSR1 | ENSG00000172939 | 0.00 | 0.00 | 0 | 0 |
| MFSD11 | ENSG00000092931 | 0.85 | 0.00 | 4 | 0 |
| ADAMTS10 | ENSG00000142303 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 268 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.