Copy Number
The putative cancer-associated PDGs driven by SCNAs in each cancer type were identified by four criteria: 1) located in a peak region of a significantly recurrent focal SNCA locus estimated by the genomic identification of significant targets in cancer (GISTIC2) algorithm, (q≤0.25); 2) altered with high frequency and large amplitude (G-score ≥0.1); 3) mRNA reliably detected in at least 10% of tumor specimens in the given cancer type (90th percentile of FPKM value ≥1); and 4) mRNA significantly and positively correlated with copy numbers (Pearson P-value less than 0.001).
| Showing page 263 |
first page | previous page | next page | last page |
| Overall_Gscore | No. of Cancer Types | ||||
| HGNC Symbol | Ensembl Gene ID | Amplification | Deletion | Amplification | Deletion |
| TXNRD1 | ENSG00000198431 | 0.00 | 0.00 | 0 | 0 |
| RPS6KA3 | ENSG00000177189 | 0.16 | 0.00 | 1 | 0 |
| C3 | ENSG00000125730 | 0.00 | 0.00 | 0 | 0 |
| CDYL2 | ENSG00000166446 | 0.00 | 0.00 | 0 | 0 |
| PAM | ENSG00000145730 | 0.00 | 0.24 | 0 | 2 |
| USP15 | ENSG00000135655 | 0.00 | 0.00 | 0 | 0 |
| NR4A2 | ENSG00000153234 | 0.00 | 0.00 | 0 | 0 |
| MAP2K3 | ENSG00000034152 | 0.16 | 0.19 | 1 | 1 |
| ROCK2 | ENSG00000134318 | 0.16 | 0.17 | 1 | 1 |
| SUOX | ENSG00000139531 | 0.00 | 0.00 | 0 | 0 |
| NR4A3 | ENSG00000119508 | 0.00 | 0.00 | 0 | 0 |
| FGR | ENSG00000000938 | 0.00 | 0.00 | 0 | 0 |
| SLC38A11 | ENSG00000169507 | 0.00 | 0.00 | 0 | 0 |
| APH1A | ENSG00000117362 | 2.68 | 0.00 | 11 | 0 |
| ZMYND8 | ENSG00000101040 | 0.33 | 0.00 | 2 | 0 |
| PKN3 | ENSG00000160447 | 0.00 | 0.11 | 0 | 1 |
| SLC5A8 | ENSG00000256870 | 0.00 | 0.00 | 0 | 0 |
| FER | ENSG00000151422 | 0.00 | 0.28 | 0 | 2 |
| RBCK1 | ENSG00000125826 | 0.33 | 0.10 | 1 | 1 |
| CYP11A1 | ENSG00000140459 | 0.00 | 0.00 | 0 | 0 |
|
Showing page 263 |
first page | previous page | next page | last page |
Copyright © 2020 University of Pennsylvania. All Rights Reserved.